Development of nanoemulsion-based in situ gel formulation of escitalopram oxalate for intranasal delivery in depression therapy

Formulation and evaluation of fluconazole-loaded in situ gel nanoemulsion using polymeric systems for ocular antifungal therapy

Findings suggest that the proposed delivery system represents a promising strategy for improving the ocular bioavailability and therapeutic efficacy of fluconazole in the treatment of fungal eye infections.

Fabrication and Evaluation of Self-Nanoemulsifying System of Mirtazapine: Enhanced Release Across Physiological pH Conditions with Improved Pharmacokinetics

Engineered polymeric nanosponge in-situ gel enables sustained and enhanced nose-to-brain delivery of quetiapine fumarate.

Quetiapine fumarate is a second-generation antipsychotic with limited oral bioavailability owing to extensive hepatic first-pass metabolism, making it a suitable candidate for intranasal brain delivery. This study aimed to develop a quetiapine fumarate-loaded nanosponge in-situ gel for sustained and enhanced brain deli...

A Thermoresponsive In Situ Salified Self-Nanoemulsifying Drug Delivery System of Olmesartan Medoxomil: Overcoming Leakage and Drug Trapping Limitations

Background/Objectives: Solid self-nanoemulsifying drug delivery systems (SNEDDS) prepared by adsorption onto porous carriers are widely used to improve the oral delivery of poorly water-soluble drugs. However, this approach is limited by increased dosing volume and incomplete drug release. This study aims to develop a...

Enhancement of Budesonide Dissolution and In-Vivo Pharmacokinetics via Nanoliposomal Drug Delivery System

Intranasal Delivery of a Thermosensitive Gel Co-loaded with Temozolomide and N-acetylcysteine: In Vitro and In Vivo Evaluation

This study was designed to develop and optimize a thermosensitive intranasal gel incorporating temozolomide (TMZ) and N-acetylcysteine (NAC) as a promising platform for direct nose-to-brain drug delivery. Formulations were fabricated via cold technique utilizing Carbopol 934P and poloxamer 407 to improve gelation and m...