Nectin-1 is a major entry receptor involved in HSV-1 infection of the brain, making its suppression before viral exposure a potential host-directed preventive strategy. siRNA can reversibly reduce Nectin-1 expression,...
In a recent article in Nature Medicine, Chen et al. describe a first-in-human study using an ASO tag to deliver a SOD1 siRNA to the central nervous system (CNS), potentially achieving faster, more extensive, and better-tolerated SOD1-lowering in ALS patients.1.
Objectives. Inflammatory diseases could arise from dysregulated innate immunity, often driven by pathogenic activation of the NLRP3 inflammasome, which promotes caspase-1-mediated maturation and secretion of interleukin-1β (IL-1β). While IL-1-blocking biologics...
[This corrects the article DOI: 10.1371/journal.ppat.1014393.].
[This corrects the article DOI: 10.3389/fphar.2026.1842007.].
The development of novel delivery systems with low toxicity and selective mitochondrial targeting is a key focus of modern cancer and other disease therapies. This work presents a series of...
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