TL;DR
It is suggested that maintaining ribosomal homeostasis via these genes acts as a barrier against EAC, highlighting their potential for risk stratification and therapeutic targeting.
LTA, EIF2AK2, and SPAG1 emerged as genetically prioritized candidates with potential biological relevance to cervical carcinogenesis, offering hypothesis-generating evidence for future mechanistic research.
This study integrates single-cell RNA sequencing, spatial transcriptomics, and Mendelian randomization to identify candidate genes associated with EC and provides insight into EC heterogeneity and support further mechanistic investigation of candidate genes associated with malignant epithelial proliferation.
This study provides a systematic multi-omics characterization of immune microenvironment remodelling in CRC and identifies candidate molecular regulators that may serve as potential targets for future immunotherapy research.
In lung adenocarcinoma (LUAD), DNA methylation-mediated gene silencing may contribute to tumor initiation, progression, and heterogeneity in treatment response. However, the key methyltransferases involved and their therapeutic potential have not been systematically characterized. This study aimed to address three majo...
In‑vitro experiments demonstrated that SLC12A8 modulates proliferation, invasion, and migration in both EM and EAOC cell lines, and support SLC12A8 as a candidate functional mediation and potential biomarker linked to EM‑EAOC pathological progression, thereby extending the mechanistic understanding of these disorders.
Background: Inflammatory bowel disease (IBD) has been linked to a two- to eightfold increase in colorectal cancer (CRC) risk. However, particular genes that bridge intestinal dysbiosis and oncogenic transcriptional reprogramming remain unclear. The Hippo/YAP pathway is a major regulator of intestinal epithelial homeost...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
