It is highlighted that Drosophila possesses high functional conservation, serving as a powerful model for human disease research across key fields such as neurodegenerative diseases, metabolic disorders, cancer, immunity, barrier function, and neuromuscular diseases.
Abstract
Simple Summary This review highlights that Drosophila possesses high functional conservation, serving as a powerful model for human disease research across key fields such as neurodegenerative diseases, metabolic disorders, cancer, immunity, barrier function, and neuromuscular diseases. It examines methods for constructing these models utilizing gene control tools and quantitative analyses and presents a framework for connecting these models through common molecular mechanisms, such as disruption of protein homeostasis, mitochondrial dysfunction, chronic inflammation, and organ-to-organ interactions. Finally, it discusses strategies for integrating Drosophila platforms into drug development, enhancing cross-laboratory reproducibility, and combining them with AI-omics to transform complex biological data into targeted therapies.
Neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, and others lack any disease-modifying therapy due to the lack of mechanistic understanding of the disease etiology. The genetic tractability, short lifespan, and conserved cellular biology of Drosophila melanogaster have positioned the...
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Zika virus (ZIKV) remains a significant global health concern owing to its association with congenital abnormalities and neurological disease. Although mammalian models have provided important insights into ZIKV biology, complementary systems are needed to enable rapid mechanistic studies and high-throughput genetic an...
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This review highlights the shift from gene disruption to precise and reversible control of gene activity by combining traditional mutagenesis techniques with cutting-edge genome-editing tools and newly developed CRISPR-based regulatory systems.
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Aging is a complex process affected by genes and modified by environment. The forefront of aging research has moved from the level of organisms to the level of tissues and single cells, analyzed using bulk tissue and single-cell transcriptomes. Transcriptomics provides high resolution, comprehensive information per s...
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Simple Summary Natural products from plants and traditional medicines are rich sources of potential new drugs, but finding them is often slow, expensive, and plagued by uncertainty about which ingredients are active and how they work. This review tackles these problems using Drosophila melanogaster—a rapid, low-cost an...
