Novel Benzimidazole–Isatin Hybrids as Potential Therapeutics for Alzheimer’s Disease: Design, Microwave-Assisted Synthesis, and Structure–Activity Relationship

Synthesis, Biological Evaluation, and In Silico Studies of Naphtalene‐Hydrazide Derivatives as Dual‐Action Agents for Alzheimer's Disease: Targeting BChE and Oxidative Stress

Interestingly, compounds 7a and 8a exhibited five‐fold higher selectivity for BChE than AChE, suggesting their potential relevance for further exploration in the context of Alzheimer's disease therapeutics.

Design and synthesis of novel benzothiazole–pyrazole derivatives: cytotoxicity against panc-1 cancer cells and EGFR, antioxidant activity, molecular docking, MD simulations, ADMET, and DFT analysis

Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study

Together with their dual cholinesterase inhibitory activities, compounds 6a and 6c represent promising multifunctional in vitro lead candidates for further development against neurodegenerative disorders associated with neurodegenerative disorders associated with neuroinflammation and oxidative stress.

Design and Synthesis of New Thiazole Derivatives for Alzheimer’s Disease Therapy as a Potential Cholinesterase Inhibitor; Toxicity Prediction and Molecular Docking Studies and Biological Evaluation

In this study, thiazole derivatives 13–23 were synthesized as novel cholinesterase inhibitors. Their structures were elucidated using 1H-NMR, 13C-NMR, and elemental analysis techniques. The binding positions and efficiencies of the designed compounds on the enzyme were investigated through molecular docking studies, an...

Computationally Guided Design and Biological Evaluation of New Benzoxazole Bridged thiazole based 1,3-Oxazole Conjugates as Potential Anti-Alzheimer's Agents: Molecular Docking, DFT and sADMET Studies

Alzheimer's disease (AD) remains one of the most devastating neurodegenerative disorders, characterized by progressive cognitive impairment associated with cholinergic dysfunction. In pursuit of potent dual cholinesterase inhibitors, a series of structurally diverse benzoxazole linked thiazole based 1,3-oxazole molec...

Harnessing Synergy: A Review on the Synthesis and Bioactivity of Artemisinin-Isatin Hybrid Molecules.

INTRODUCTION To examine the design, synthesis, and pharmacological potential of novel artemisinin-isatin hybrid compounds as a strategy to overcome drug resistance and expand therapeutic applications beyond malaria. METHODS Researchers employed molecular hybridization techniques-specifically Cu-promoted azide-alkyne...