Aug 2026· Journal of pediatric ophthalmology and strabismus· pp.
1-8
· 0 citations· 26 references
Medicine
TL;DR
Use of a dichoptic digital therapeutic device in the treatment and management of amblyopia holds exciting potential in deprivation amblyopia, although a percentage of patients with severe amblyopia did show modest improvement.
Abstract
Purpose
To report the treatment of deprivation amblyopia with Luminopia (Luminopia, Inc), a digital therapeutic device using dichoptic viewing that received U.S. Food and Drug Administration approval for the treatment of anisometropic amblyopia in children 4 to 12 years of age.
Methods
Twenty-two pediatric patients prescribed the Luminopia device for deprivation amblyopia following childhood cataract or glaucoma surgery or congenital corneal opacity with at least 3 months of follow-up were identified. Best corrected visual acuity (BCVA) was compared to pretreatment at each follow-up visit. Total prescribed hours, usage, adherence, and completion of supplemental amblyopia treatment were analyzed.
Results
Fifty-five percent of patients were boys, and the average age was 6.45 ± 3.0 years (mild to moderate amblyopia: 7.0 ± 3.1 years; severe amblyopia: 6.0 ± 3.0 years). At the 3-month follow-up visit, in the mild to moderate amblyopia cohort, 5 of the 8 patients (62.5%) showed at least one line of improvement in their BCVA in the amblyopic eye. One patient (12.5%) had the same BCVA, and 2 (25%) had decreased BCVA. In contrast, in the severe amblyopic cohort, 6 patients (50%) had improved, 5 (42%) had stable BCVA, and 1 (8%) had decreased BCVA.
Conclusions
Use of a dichoptic digital therapeutic device in the treatment and management of amblyopia holds exciting potential in deprivation amblyopia. Those with mild to moderate amblyopia appear to achieve greater visual acuity improvement compared to those with severe amblyopia, although a percentage of patients with severe amblyopia did show modest improvement.
Luminopia demonstrated significant improvements in Registry patients with severe amblyopia, particularly in treatment-naive patients, supporting its use as a viable treatment option that may address key limitations of traditional approaches.
Courtney L. Kraus, A. Godfrey, E. Gaier et al.· Journal of AAPOS· 1 citation
Administering vision therapy in conjunction with patching significantly improved VA, stereo acuity, and accommodation facility in bilateral refractive amblyopia compared to patching alone.
Saeedeh Hoseinmenni, S. Rahmani, Ebrahim Jafarzadehpour et al.· Journal of Ophthalmic & Visi...· 0 citations
PURPOSE
To evaluate long‑term visual acuity (VA) trends following a structured vision therapy protocol in patients with amblyopia who had plateaued after conventional occlusion therapy.
METHODS
This prospective cohort study included 157 patients diagnosed with amblyopia who showed no further VA improvement over at least three consecutive assessments during standard patching. All participants received individualized vision therapy comprising monocular and binocular exercises, fusion training, fixation stabilization, and perceptual tasks, combined with limited daily occlusion (1-3 hours). Therapy was delivered over 15 weekly in‑clinic sessions, followed by a structured home program. Visual acuity was monitored every 6 months over a 48‑month follow‑up period.
RESULTS
A total of 177 amblyopic eyes from 157 patients (mean age 15.56 ± 10.6 years) were analyzed. Mean VA improved from 0.50 ± 0.23 at baseline to 0.70 ± 0.28 at 48 months (p < .001); 48.6% of eyes achieved a final VA of ≥0.8 decimal. Significant VA gains were observed across all age groups, with mean improvements of 0.24, 0.21, and 0.16 in decimal VA for ages ≤ 8 years, 8-18 years, and >18 years, respectively. The proportion of patients gaining ≥ 2 lines of VA was highest in the ≤8 years (62.5%) and 8-18 years (62.5%) groups, compared with 35.4% in those > 18 years. Isoametropic amblyopia showed the highest rate of ≥2‑line improvement (65.0%), followed by strabismic (63.6%) and anisometropic (44.2%) types. No statistically significant difference in visual outcomes was observed between the two protocols (Haidinger's brushes/flashing vs. adding perceptual learning; p = .385).
CONCLUSION
Vision therapy can produce clinically meaningful and durable visual improvements in amblyopic patients who no longer respond to occlusion alone. The present study also supports extending amblyopia treatment into adolescence and adulthood, while emphasizing the need for tailored approaches based on the etiology of amblyopia and age.
Hassan Hashemi, Alireza Jamali, E. Jafarzadehpur et al.· Strabismus· 0 citations
Among all amblyopia types, anisometropic amblyopia is the most common. For many eye care professionals, treating amblyopia, including anisometropic amblyopia, has proved challenging. Although optical rectification followed by individual eye fixing is the highest quality level for treating amblyopia in youngsters, not all patients recuperate their ordinary visual acuity as a result of this treatment. Anaglyphic red-green channels will be used to test the impact of privately situated dichoptic visual therapy on a sample of young adults with non-strabismic anisometropic amblyopia's stereo acuity. The research was cross-sectional and observational in nature. Young individuals with non-strabismic amblyopia were isolated into two groups (exploratory and control) and contrasted with an age-matched control group without amblyopia using purposive inspecting. Before getting locally situated dichoptic treatment, all patients in the two groups were required to wear their scene amendment continuously for no less than about four months to work with refractive adaption. The Sound system Fly test was used to quantify sound system acuity when 40 hours of locally established dichoptic treatment. From pattern information, the progressions in sound system acuity following ten weeks (40 hours) of preparing were found. The Mann-Whitney U-test was used to think about the middle distinctions between the trial and control groups, with P value < 0.05. Young individuals with moderate non-strabismic anisometropic amblyopia profited from locally situated dichoptic treatment for their sound system acuity. Thus, demonstrating that the binocularity could further develop in anisometropic adult amblyopes through a therapeutic methodology that might be more useful and preferable suit their requesting way of life over conventional centre based treatment.
Rakibul Hasan Khan, Smita Das, Tajbiara Begum et al.· Genetics and Molecular Resea...· 0 citations
Active vision therapy leads to significant and accelerates improvements in CS among children with bilateral refractive amblyopia and demonstrates a rate of change in monocular CS of 0.05 during follow-up time.
Saeed Rahmani, Saeedeh Hoseinmenni, C. Dehghani et al.· International Journal of Oph...· 0 citations
PURPOSE
To describe a specific pattern of esotropia observed in myopic patients occurring exclusively while wearing refractive correction despite a normal accommodative convergence / accommodation (AC/A) ratio and to evaluate the efficacy of its management.
METHODS
This is a retrospective study which included children and young adults with high myopia who presented with esotropia with spectacles or contact lenses correction only, and orthophoria or near orthophoria without optical correction. AC/A ratio was measured using gradient method. Ductions and versions were evaluated. The angles of deviations were measured with and without optical correction, for both distance and near. Magnetic resonance imaging of the extraocular muscles was performed. The target angle for surgical correction was the preoperative angle of esotropia at distance with spectacle correction, and the changes in the angles of deviation after surgery were evaluated.
RESULTS
Nine patients were identified. The mean age at presentation was 13.6 ± 5.2 years; 6 patients were females (66.7%). The mean angle of esotropia with optical correction was 44 ± 5 PD for distance and 43 ± 4 PD for near. The mean angle of esotropia for near without optical correction was 4 ± 3 PD. Mean spherical equivalent was -10.6 ± 1.8 Diopters. All patients underwent bilateral medial rectus muscle recession. Mean medial muscle recession was 6.9 ± 0.4 mm. Mean follow up was 8 ± 4 months. Successful outcome was achieved in 8 patients, one patient had residual esotropia of 25 PD. None of the patients developed exotropia without glasses after surgery.
CONCLUSION
Esotropia in myopic patients may appear only with optical correction, including glasses or contact lenses. The exact cause of the absence of esotropia without optical correction cannot be confirmed but cannot be attributed to a high AC/A ratio. These patients benefit from bilateral medial rectus recession similar to those who have esotropia without optical correction, without carrying the risk of overcorrection without spectacles or contact lenses.
Heba M. Fouad, Ahmed Awadein· Seminars in Ophthalmology· 0 citations