Open access
Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety
A. Di Costanzo
Ilaria Pirona
L. D'Erasmo
S. Buonaiuto
Vincenza Colonna
Allegra Via
D. Tramontano
Carlo Maiorca
Marcello Arca
Medicine
Abstract
This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).