The porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity than those of PLGA with a lower lactide/glycolide (LA/GA) molar ratio, demonstrating their potential for tissue engineering applications.
The scaffold showed the highest osteoinduction, and the scaffold with 530 ± 56 μm average pore diameter demonstrated the highest expression of osteodifferentiation marker genes in DPSCs, and the addition of nanoparticles into the polymer matrix led to the decrease in the expression of pro-inflammatory genes in macrophages.
A. V. Yushkov, E. A. Kuvshinova, I. Bulygina et al.· Biomedical Materials· 0 citations
Carboxymethyl chitosan (CMCh) is a water-soluble chitosan derivative with excellent biocompatibility and biodegradability, making it a promising material for tissue engineering and controlled drug delivery. In this study, three-dimensional (3D) scaffolds based on a 50/50 CMCh/poly(N-vinylpyrrolidone) (PVP) mixture were modified with tannic acid (TA) or citric acid (CA) as cross-linking agents and fabricated by freeze-drying. The effects of these cross-linking agents on scaffold morphology, physicochemical properties, and cytocompatibility were evaluated using infrared spectroscopy (IR), microscopy, swelling tests, thermogravimetric analysis (TGA), mechanical testing, and in vitro cytotoxicity assays. Both cross-linking agents altered the scaffold morphology, swelling behaviour, and mechanical properties. The swelling capacity reached 1280 ± 37% for 50/50/TA and 1345 ± 145% for 50/50/CA, while the compressive modulus decreased from 505 ± 103 kPa for the unmodified scaffold to 188 ± 31 kPa for the 50/50/CA scaffold. TA promoted the formation of smaller pores (<130 μm), whereas CA produced smoother scaffold surfaces. Cross-linking slightly improved the thermal stability of the scaffolds, and IR analysis confirmed intermolecular interactions between the polymer matrix and the TA or CA molecules. The modified scaffolds exhibited high porosity (approximately 90%) and supported cell proliferation without cytotoxic effects, demonstrating their potential as biomaterials for tissue engineering and other biomedical applications.
M. Szulc, Sandra Lewandowska, T. Jędrzejewski et al.· Journal of Materials Science...· 0 citations
In this study, a polylactic acid (PLA)/tea polyphenols (TP) polymer blend was developed for coronary artery stents. Using a high-efficiency mixer, we prepared optimal mixtures, which were then hot- and cold-pressed into thin films of varying thicknesses. Scanning electron microscopy (SEM) and contact angle tests were used to analyze surface changes and biodegradability over time. The mechanical properties of drug-loaded films were evaluated via a universal testing machine. Tea polyphenols enhanced specimen hydrophilicity, biocompatibility, and stability by reinforcing the microstructure. This is crucial for long-term implants as it extends service life and minimizes complications from material fatigue.
Xu-Yu Sun· SAE technical paper series· 0 citations
The obtained results confirm the potential of PLA-based composites modified with hydroxyapatite and gentamicin as functional biodegradable materials for implant applications in regions with moderate mechanical loading, combining mechanical support, bioactivity, and local antimicrobial protection.
A. Khrustaleva, A. Yedrissov, D. Khrustalev et al.· Medicine and ecology· 0 citations
The in-vitro experiment revealed that the PCL-CQ composite electrospun scaffold showed better MG63 cell adhesion and growth compared to the control PCL scaffold and thus could be a potential scaffold material for bone defect applications.
P. Harikrishnan, Kayal Vizhi Kumaravel, Arayambath Balamani et al.· Trends in Biomaterials & Art...· 0 citations
The results showed that the composite scaffolds effectively improved the inflammatory microenvironment in the defect region, promoted macrophage polarization toward an anti-inflammatory phenotype, enhanced cellular osteogenic activity and mineralization, and facilitated new bone formation and tissue reconstruction.
Fang Tong, Ting-Ting Lu, Lu Tang et al.· Journal of materials chemist...· 0 citations
