TL;DR
This pilot study annotated exploratory urinary metabolic alterations in treated patients with BD during a manic episode, and revealed a statistically significant but modest group-related metabolic difference, with limited discriminatory performance in OPLS-DA modelling.
Background Major depressive disorder (MDD) is increasingly recognized as a systemic condition accompanied by metabolic disturbances, particularly in lipid metabolism. However, whether MDD is associated with the development of chronic pancreatitis (CP), a chronic inflammatory disease with substantial metabolic and nutri...
Bipolar disorder (BD) is a heterogeneous mood disorder that lacks robust biomarkers for biological stratification. We used high-throughput plasma proteomics to characterize case-control differences, identify proteomic subgroups within BD, and examine their associations with blood-based markers and clinical features. Pl...
Objective To investigate urinary metabolite differences between subgroups stratified by anhedonia severity in patients with major depressive disorder (MDD) and identify potential biomarkers associated with anhedonia using untargeted metabolomic profiling. Methods Fifty-five MDD patients were recruited and stratified by...
These findings identify distinct cortical morphometric organization in BDD and MDD, and these differences are linked to transcriptomic, cellular, and neurotransmitter-related annotations, providing multiscale insights into the neurobiological divergence between the two disorders.
This study suggests that BD patients present significant differences in gene expression patterns compared to healthy controls, and pathway analyses suggest that protein misfolding and endoplasmic reticulum alterations could be implicated in the pathophysiology of BD, while response to lithium might be related to modula...
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