Open access
Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma
Chang-Xin Zhan
Ting Xu
Hong-Shen Lai
Yi-Feng He
Feng-Jie Chen
Rui-Jian Liu
Bang-Qi Wang
Zhu Wang
Hui Liang
De-Qin Zeng
Medicine
TL;DR
An IBD-CRC shared host–microbe signature predicts prognosis in BLCA and single-cell and spatial analyses reveal malignant cell heterogeneity linked to signature activity.
Abstract
Highlights • An IBD-CRC shared host–microbe signature predicts prognosis in BLCA.• The LASSO risk score is associated with basal/squamous features and immune exhaustion.• Single-cell and spatial analyses reveal malignant cell heterogeneity linked to signature activity.• WSI-based attention MIL predicts molecular risk status from routine H&E slides.• RF-SHAP and SNV/CNV analyses identify risk score-associated molecular features.