Sep 2026· Trends in Genetics· 0 citations· 100 references
Medicine
TL;DR
This review explores the current understanding of intrinsic molecular features dictating circRNA stability and provides an integrated perspective for understanding circRNA-centered regulation of RNA stability.
Abstract
Circular RNAs (circRNAs) are a class of covalently closed, single-stranded RNAs generated predominantly through back-splicing of pre-mRNAs. Unlike their linear counterparts, circRNAs lack free 5' and 3' termini, rendering them intrinsically resistant to exoribonucleolytic degradation and conferring exceptional stability. In addition, accumulating evidence has revealed that circRNAs actively participate in regulating the stability of other RNA species. This review explores the current understanding of intrinsic molecular features dictating circRNA stability. Furthermore, we emphasize recent progress on how circRNAs crosstalk with and regulate the stability of other RNA species, including mRNAs and microRNAs, through various mechanisms. Ultimately, we provide an integrated perspective for understanding circRNA-centered regulation of RNA stability.
How circRNAs regulate homeostasis in normal tissues, how dysregulated expression of circRNAs impacts various cancers and emerging therapeutic technologies that build upon their unique features are reviewed.
Aaron C. Chack, C. Pecot· Frontiers in epigenetics and...· 0 citations
This chapter provides an overview of numerous computational approaches developed to reconstruct circRNA-miRNA-mRNA networks, ranging from specific circRNA-oriented applications to sequencing-based tools, each with distinct strengths and limitations.
S. Avesani, L. Cascione, R. Giugno· Methods in molecular biology· 0 citations
Circular RNAs (circRNAs) are generated by backsplicing of eukaryotic protein-coding transcripts and can regulate microRNAs and RNA binding proteins, or serve as translation templates. Their covalently closed structure confers resistance to exonuclease-mediated degradation, extending their half-life and supporting their...
Christopher J. Fields, Rina Fujiwara, Bradley W. Wright et al.· bioRxiv· 0 citations
Circular ribonucleic acids (RNAs) are made by alternative splicing of the pre-messenger RNA (pre-mRNA), connecting a downstream splice site with an upstream splice site, thus encompassing any introns and exons in between and circularizing the molecule. Various mechanisms are involved in forming the circular RNAs employ...
I. Al-Janabi· Jordan Journal of Pharmaceut...· 0 citations
This review delineates the classical, RNAse III-dependent small RNA processing activities from an expanding set of noncanonical functions in which Dicer operates independently of RNAi outputs, and proposes an integrated conceptual framework in which Dicer acts as a multifunctional regulator of chromatin architecture an...
Rareș Drula, Swathi Arur· Annual Review of Genetics· 0 citations
Circular RNAs (circRNAs) are an emerging class of RNA molecules involved in development and disease. They are generated through back-splicing from pre-mRNA. RNaseR treatment, which degrades linear RNA while preserving circRNAs, is widely used for circRNA validation and enrichment. This short report demonstrated differe...
Lotte Ulrix, J. De Waele, J. Vandesompele et al.· bioRxiv· 0 citations
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