Open access
Fetal Brain Abnormalities in Trisomy 21 and Associated Neurodevelopmental Outcome: Key Factors to Identify Differences in Neurodevelopmental Outcome?
C. Haberl
P. Palmrich
Eva Karner
P. Kienast
S. Glatter
F. Heinzl
P. Moser
D. Prayer
Gregor Kasprian
J. Binder
Medicine
Abstract
Trisomy 21 (T21) is associated with various neurological impairments. However, the mechanisms of fetal brain development in T21 and their impact on neurodevelopmental outcomes remain unclear, limiting prenatal counseling. Therefore, this study aims to assess neuropathological changes in fetuses with T21 and the associated neurodevelopmental outcome.