It is argued that brain tumors should be viewed not as disorganized cellular masses but as aberrant developmental systems, and defining the developmental dependencies and circuit vulnerabilities of malignant progenitor states may enable more precise therapies that target tumor biology while preserving essential brain function.
Medulloblastoma is increasingly best understood not simply as a cell-autonomous embryonal tumour, but as a family of molecularly and anatomically distinct diseases shaped by the developing cerebellum and posterior fossa. The four principal molecular subgroups—WNT, sonic hedgehog, Group 3 and Group 4—differ not only in...
Neuroepithelial tumors, including diffuse gliomas and embryonal neoplasms, remain among the most lethal cancers despite major advances in molecular diagnostics and some novel targeted therapies for subsets of patients. A persistent barrier to progress is the lack of a unifying framework that integrates their cellular h...
L. Padevit, Tobias Weiss, F. Vasella et al.· Journal of Clinical Oncology· 0 citations
Highlights What are the main findings? Neuroinflammation in CNS tumors, especially glioblastoma, is an active driver of tumor progression, rather than a passive bystander, through coordinated interactions among myeloid cells, astrocytes, lymphocytes, and tumor cells within the microenvironment. Tumor-promoting inflamma...
Cristina Cueto-Ureña, M. Ramírez-Expósito, J. Martínez-Martos· Cells· 0 citations
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid progression and poor prognosis. Central to GBM pathobiology are glioma stem cells (GSCs), which preferentially localize within the perivascular niche (PVN) and sustain tumor growth, invasion, and therapeutic resis...
Twinkle Jina Minette Manoharan, K. Ravi, Shwetal Mehta et al.· Lab on a Chip· 0 citations
Summary Adult diffuse gliomas comprise malignant cell states interwoven with the non-malignant brain microenvironment. Here, we combine spatial transcriptomics and spatial proteomics of isocitrate dehydrogenase (IDH)-mutant gliomas to define organizational principles across histological grades. In low-grade tumors, spa...
Rouven Hoefflin, Alissa Greenwald, Noam Galili Darnell et al.· Cancer Cell· 1 citation
It is suggested that histone H3.3 K27M mutations drive diffuse midline glioma by ablating intrinsic regional differences in oligodendrocyte development, selectively expanding immature oligodendrocyte precursor cell populations in the brainstem while disrupting normal differentiation programs.
Jared M. Andrews, K. Budd, C. Kwon et al.· Nature Communications· 0 citations
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