It is argued that brain tumors should be viewed not as disorganized cellular masses but as aberrant developmental systems, and defining the developmental dependencies and circuit vulnerabilities of malignant progenitor states may enable more precise therapies that target tumor biology while preserving essential brain f...
Costanza Lo Cascio, A. Martija, M. Filbin et al.· Neuro-Oncology· 0 citations
Human cortical organoids recapitulate key features of radiation-induced neural injury, recovery, and therapeutic modulation, providing a robust, scalable, and human-relevant platform for studying CNS radiation biology and preclinical screening of candidate radiation mitigators.
Ling He, H. Kornblum, A. Bhaduri et al.· Stem Cells Translational Med...· 0 citations
Exosome-mediated intercellular communication is identified as a potential mechanism regulating GBM cellular homeostasis, treatment resistance, and recurrence and is used to establish a bidirectional feedback circuit between stem-like and differentiated tumor-cell compartments.
Linda Azizi, Ling He, A. Bhaduri et al.· bioRxiv· 0 citations
A consolidated cellular-resolution transcriptomic atlas of human brain development from the onset of neurogenesis to adulthood is presented, covering ∼2.2 million cells from 156 donors across nine studies, and dynamic gene programs predictive of cell-type maturation are identified.
Sridevi Venkatesan, Patricia R. Nano, Jonathan M. Werner et al.· bioRxiv· 0 citations
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