Sep 2026· Journal of Clinical Lipidology· 0 citations· 45 references
Medicine
TL;DR
Lp(a) is associated with subclinical atherosclerosis, and imaging for subclinical atherosclerosis is useful for risk-stratifying individuals with elevated Lp(a), and CAC scoring has demonstrated utility for risk stratification among individuals with elevated Lp(a).
Abstract
Background
Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease.
SOURCES OF MATERIAL
Literature review.
ABSTRACT OF
Findings
A large body of evidence has established the association between Lp(a) and subclinical atherosclerosis. In particular, Lp(a) is associated with coronary artery calcium (CAC), coronary artery plaque identified by coronary computed tomography angiography (CCTA), and carotid artery plaque. Lp(a) is more strongly associated with noncalcified coronary artery plaque than calcified plaque. In addition, CAC scoring has demonstrated utility for risk stratification among individuals with elevated Lp(a). The role of CCTA and carotid imaging to risk-stratify individuals with elevated Lp(a) in a primary prevention setting remains to be established.
Conclusions
Lp(a) is associated with subclinical atherosclerosis, and imaging for subclinical atherosclerosis is useful for risk-stratifying individuals with elevated Lp(a).
BACKGROUND
Lipoprotein(a) [Lp(a)] is a genetically determined, causal risk factor for atherosclerotic cardiovascular disease. Whether elevated Lp(a) is associated with premature coronary artery disease (pCAD) in young and middle-aged adults with low levels of low-density lipoprotein cholesterol (LDL-C) remains poorly c...
Yahya Bawahab, V. C. Vasile· Journal of Clinical Lipidolo...· 0 citations
Background and aims Elevated lipoprotein(a) [Lp(a)] levels are recognized as a genetic risk factor for atherosclerotic cardiovascular disease. Previous coronary imaging studies have linked elevated Lp(a) levels to vulnerable coronary plaque characteristics. However, the relationship between elevated Lp(a) levels and vu...
K. Kojima, Yudai Tanaka, Katsunori Fukumoto et al.· Atherosclerosis Plus· 0 citations
This meta-analysis suggests that high Lp(a) levels are associated with several imaging-defined high-risk coronary plaque features, with the most robust evidence observed for OCT-derived TCFA and plaque rupture.
Jia-Yu Zhang, Yang Tang, Yu-Yang Cao et al.· International Journal of Car...· 0 citations
Emerging evidence links Lp(a) to atrial fi brillation, broadening its clinical relevance and integrating Lp(a) testing into risk assessment and preparing for targeted therapies are critical steps in modern cardiovas-cular prevention.
L. Kopaleishvili, T. Chkhaidze, S. Ungiadze et al.· Bulgarian Cardiology· 0 citations
Although low-density lipoprotein cholesterol (LDL-C) can now be effectively reduced, substantial residual risk of acute ischemic cardiovascular events persists. Lipoprotein(a) [Lp(a)] is an established causal risk factor for atherosclerotic cardiovascular disease (ASCVD), yet its mechanistic links to plaque vulnerabili...
Quan-Hao Sun, Ya-Jie Wang, Xiao-Ya Li et al.· Biomedicines· 0 citations
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