Hyperuricemia has an established association with increased blood pressure, and as both variables increase cardiometabolic risks independently, early identification and prompt management of these two along with other risk factors is essential to reduce the morbidity and mortality outcomes overall.
Background Hyperuricemia frequently accompanies heart failure (HF), yet hospital-based real-world data from China remain insufficient. We therefore evaluated the burden of hyperuricemia in hospitalized patients with HF and explored its associated clinical correlates. Methods We carried out a retrospective cross-sectional analysis of 1,985 patients admitted with HF. Hyperuricemia was defined as serum uric acid ≥ 7.0 mg/dL in males and ≥ 6.0 mg/dL in females. Candidate correlates were examined using univariable and multivariable logistic regression models. To further characterize the findings, we additionally applied restricted cubic spline analyses, and subgroup analyses by sex and age, and NYHA class. Results The overall prevalence of hyperuricemia was 69.42%. Prevalence was similar across sex, age, and BMI groups, but differed by NYHA class. In the multivariable model, hyperuricemia was independently associated with markers of renal dysfunction, hemodynamic impairment, electrolyte imbalance, and metabolic disturbance. RCS analyses suggested nonlinear associations for potassium, BNP, eGFR, and HDL-C. Conclusion Hyperuricemia was highly prevalent among hospitalized patients with HF and was associated with multiple markers of renal dysfunction, hemodynamic impairment, electrolyte imbalance, and metabolic disturbance. These findings provide real-world evidence suggesting that hyperuricemia in hospitalized HF patients may reflect a broader cardiorenal and metabolic profile.
Lingqin Li, Xinzhu Yuan, Yanni Zhang et al.· Frontiers in Medicine· 0 citations
Background/Objectives: Asymptomatic hyperuricemia is a common yet frequently overlooked condition in the management of patients with type 2 diabetes mellitus (T2DM), despite its potential association with cardiovascular events. This study aimed to determine the prevalence and associated factors of asymptomatic hyperuricemia among patients with T2DM. Methods: A cross-sectional study was conducted on 235 patients with T2DM at a tertiary hospital. Demographic, clinical, laboratory, and medication data were collected. Asymptomatic hyperuricemia was defined as a serum uric acid level ≥ 420 µmol/L in men or ≥360 µmol/L in women, in the absence of clinical symptoms of gout. Hyperuricemia was classified by severity, and logistic regression analysis was used to identify associated factors. Results: The prevalence of asymptomatic hyperuricemia was 31.1%, including 25.9% with mild hyperuricemia (serum uric acid 420–540 µmol/L in men and 360–540 µmol/L in women) and 5.1% with severe hyperuricemia (serum uric acid > 540 µmol/L). Independent associated factors included body mass index (adjusted OR: 1.18; 95% CI: 1.01–1.36; p = 0.032), alcohol consumption (adjusted OR: 6.05; 95% CI: 1.79–20.41; p = 0.004), and lower estimated glomerular filtration rate (eGFR) (adjusted OR: 0.96; 95% CI: 0.93–0.99; p = 0.012). Subgroup analyses based on sex, renal function, and alcohol use demonstrated that these factors remained significant. The area under the receiver operating characteristic (ROC) curve for the predictive model was 0.869 (95% CI: 0.818–0.920). Conclusions: Asymptomatic hyperuricemia is prevalent in patients with T2DM (31.1%) and is associated with modifiable risk factors such as overweight, alcohol consumption, and chronic kidney disease. Our findings suggest that serum uric acid assessment may be useful as part of a comprehensive cardiovascular–renal–metabolic risk evaluation in patients with type 2 diabetes mellitus. However, prospective studies are needed to determine whether routine screening improves clinical outcomes.
Kim Son Tran, M. Võ, M. Nguyen· Diagnostics· 0 citations
Background: Hypertension is one of the most prevalent chronic conditions worldwide and a major contributor.
It is a major modifiable risk factor for cardiovascular disease, stroke, heart failure, and renal impairment. The
complications of hypertension are not confined to the cardiovascular system; target organ damage in the kidneys
is of equal concern and is often silent until advanced stages. Microalbuminuria, defined as a urinary albumin
excretion of 30–300 mg/24 hours, has been increasingly recognized as a sensitive and early indicator of renal
involvement in hypertension. From a clinical perspective, detecting microalbuminuria provides an opportunity
for early intervention.
Methodology: This is study was conducted in the Department of General Medicine. 100 patients who match the
inclusion and exclusion criteria have been selected by random sampling method and included in the study. Patients who were diagnosed with essential hypertension (already known or newly diagnosed) were selected from
outpatient clinic and wards of tertiary care teaching hospital after applying inclusion and exclusion criteria.
Results: Prevalence of microalbuminuria in this study was 33%. Distribution of microalbuminuria in different
sex 35.2% males and 30.43% females had microalbuminuria. 54 patients were males and 46 patients were females out of 100 hypertensives. Microalbuminuria was present in 32.3% of non-smokers and 34.2% of smokers.
65 patients out of 100 were non-smokers and 35 patients were smokers. Out of 33 patients with microalbuminuria, 1 patient had normal fundus. 8 patients had grade 1 hypertensive retinopathy, 19 had grade 2 hypertensive
retinopathy, 5 patients had grade 3 hypertensive retinopathy. This is statistically significant (p<0.00001). 22
people out of 35 patients with LVH on ECG had microalbuminuria. This is statistically significant (p<0.00001).
10 out of 56 patients with normal cardia on echocardiography had microalbuminuria and 23 out of 44 patients
with LVH/cardiac dysfunction had microalbuminuria. This value is statistically significant.
Conclusion: Microalbuminuria was detected in 33% of patients with essential hypertension, indicating its role
as an early marker of target organ damage. A strong and statistically significant association was found between
microalbuminuria and hypertensive retinopathy (fundus changes), left ventricular hypertrophy (LVH), and cardiac dysfunction on 2D-ECHO, highlighting its correlation with cardiovascular morbidity
Chaurasia Priyanka, Asiya Zeba, Prakash Prakash· International Journal of Pha...· 0 citations
Background: Inflammation is a critical factor in the development and progression of hypertension, cardiovascular disease, and kidney disease. Accordingly, elevated levels of inflammatory markers, such as high-sensitivity C-reactive protein (HSCRP), have been reported in patients with hypertension.
Objective: This study aimed to evaluate serum HSCRP levels and albuminuria and to determine their correlation in patients with hypertension.
Methods: This cross-sectional study involved 300 participants, comprising 200 individuals with hypertension and 100 normotensive individuals, and was conducted at Delta State Central Hospital, Warri, between October 2022 and December 2023. An interviewer-administered structured questionnaire was used to collect demographic and clinical data, which were analysed using SPSS version 23.
Results: Mean HSCRP levels were 4.23 ± 3.31 mg/L in the hypertensive group and 1.50 ± 1.49 mg/L in the control group; the difference was statistically significant (p < 0.001). Mean urine albumin-to-creatinine ratio (UACR) values were 1.02 ± 1.42 mg/mmol in the hypertensive group and 0.28 ± 0.16 mg/mmol in the control group; this difference was also statistically significant (p < 0.001). A statistically significant weak positive correlation was observed between HSCRP and UACR in the hypertensive group (r = 0.140, p = 0.048).
Conclusion: Serum HSCRP and UACR levels were significantly higher in patients with hypertension than in controls. HSCRP and UACR showed a weak positive correlation in the hypertensive group.
A. Eguvbe, E. Umukoro, Pedro Ejomafuvwe Amrevwodjemu et al.· Asian Journal of Medicine an...· 0 citations
Background: Resistant hypertension is a major clinical challenge, and it is linked to a high cardiovascular risk.
Although there is a guideline-based therapy, not all patients can reach the maximum levels of blood pressure
control, which is often explained by metabolic, lifestyle, or adherence-related factors.
Objective: To establish the prevalence and risk factors of resistant hypertension in patients visiting the General
Medicine OPD of a tertiary care hospital.
Methodology: The study was a cross-sectional observation based on 180 hypertensive adults in a hospital. The
structured proforma was used to record demographic information, lifestyle, comorbidities, treatment, and
medication compliance. Standardized methods were used in measuring blood pressure, resistant hypertension was
defined as the uncontrolled BP in the presence of 3 or more antihypertensive drugs, including a diuretic. The
statistical analysis was done using SPSS.
Findings: Resistant hypertension was common (17.8% or 32/180). The prevalence rates of diabetes mellitus
(71.9%), obesity (68.8%), disordered sleep (53.1%), dyslipidemia (56.2%), and non-adherence to therapy (43.8%)
were much higher in the resistant cases than in non-resistant patients. There were slight differences in smoking
and drinking alcohol.
Conclusion: Resistant hypertension is a serious condition that impacts close to a fifth of patients with
hypertension and it is closely linked with metabolic abnormality, sleeping disorders, and poor adherence to
medication. To enhance the BP regulation and prevent complications, early diagnosis and specific actions are
required.
Nilashish Dey· International Journal of Pha...· 0 citations
Background: Hypertension is a prevalent chronic condition globally and poses a significant public health burden in relation to cardiovascular diseases, stroke and renal diseases. Identification of the disease at an early stage and associated risk factors are necessary for successful prevention and control. Aim: To evaluate selected demographic and clinical features of adult subjects and to assess the relationship between selected risk factors and hypertension history. Materials and methods: We performed a cross-sectional study on 160 adult subjects. A structured questionnaire on demographic features, anthropometric measurements, blood pressure, history of hypertension, and use of antihypertensive drugs, was administered. Data were analyzed using descriptive statistics, Chi-square testing and statistical significance was set at P < 0.05. Results: The study population consisted of 160 subjects (n=80 hypertensive patients and n=80 normotensive controls). And 46.2% of those with hypertension were obese, 33.8% were overweight. Based on ACC/AHA categorization, 48.75% were in Stage 1 HTN and 42.5% in Stage 2 HTN. The hypertensive group also had significantly greater systolic and diastolic blood pressure, and body weight than the control group (P < 0.05). Conclusion: Findings, this clearly demonstrates that hypertension remains a significant public health issue, associated with several demographic and behavioral characteristics . Promoting healthy lifestyle, blood pressure screening, and early treatment intervention may help alleviate the hypertension load in the society.
Raghad Jabbar· Libyan Journal of Applied an...· 0 citations