SKN attenuates DOX-induced myocardial injury, senescence, and fibrosis and is associated with improved redox and mitochondrial homeostasis and suppression of p53/p21-associated senescence signaling, with DRP1-related mitochondrial dysregulation contributing to the protective effects of SKN.
Background/Objectives: Doxorubicin (DOX) is an effective chemotherapeutic agent whose clinical use is limited by dose-dependent cardiotoxicity that may progress to irreversible heart failure. Celastrol (Cel), a bioactive triterpenoid from Tripterygium wilfordii, has recognized anti-inflammatory and antioxidant activiti...
Yang Zhang, Jing-Yi Qi, Ming-Yang Cui et al.· Pharmaceuticals· 0 citations
NoB protects against DOX-induced cardiotoxicity by promoting PKM2 tetramerization, thereby preserving mitochondrial function, restoring cellular energy metabolism, and reducing oxidative stress and cardiomyocyte apoptosis.
Xin-Qing Dai, Ming-Yue Tang, Ya Wu et al.· European Journal of Pharmaco...· 0 citations
It is discovered that ITG inhibits oxidative stress and safeguards mitochondrial morphofunctional homeostasis in response to pathological stress through activating SIRT6/FOXO1 axis, suggesting the therapeutic potential of ITG in the treatment of cardiac hypertrophy and remodeling.
Jia-Hao Li, Dan Li, Fei-Xue Xu et al.· Acta Pharmacologica Sinica· 0 citations
Myocardial ischemia/reperfusion (I/R) injury impairs the prognosis of patients with cardiovascular disease. Reperfusion induces cardiomyocyte apoptosis and dysregulates autophagy, thereby disrupting cellular homeostasis and exacerbating myocardial injury. Bisdemethoxycurcumin (BDMC), a major active component of Curcuma...
Li-Min Liu, Na-Na Chen, Xin-Ping He et al.· European Journal of Pharmaco...· 0 citations
Apoptosis and mitochondrial bioenergetic dysfunction are hallmarks of cardiotoxicity that drive cardiac damage, particularly following exposure to chemotherapeutic agents such as doxorubicin. Doxorubicin induces pro-apoptotic signaling and disrupts mitochondrial homeostasis and cellular energy metabolism, leading to ca...
Hnin Ei Ei Khine, S. Mangmool, Warisara Parichatikanond· Biochemical Pharmacology· 0 citations
Oxidative stress is a major contributor to cardiomyoblast injury and cardiovascular disease progression. Huperzine A (HupA), a natural Lycopodium alkaloid, exhibits antioxidant and anti-inflammatory properties, but its cardioprotective mechanisms remain unclear. This study aimed to investigate the effects of HupA on ox...
Yu-Song Zhang, Hong-Xia Long, Li Qiao et al.· Antioxidants· 0 citations
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