Targeting mitochondrial morphofunctional homeostasis and oxidative stress: Iristectorigenin A protects against cardiac remodeling via SIRT6/FOXO1 signaling.
Oct 2026· Acta Pharmacologica Sinica· 0 citations· 41 references
Medicine
TL;DR
It is discovered that ITG inhibits oxidative stress and safeguards mitochondrial morphofunctional homeostasis in response to pathological stress through activating SIRT6/FOXO1 axis, suggesting the therapeutic potential of ITG in the treatment of cardiac hypertrophy and remodeling.
Oxidative stress is a major contributor to cardiomyoblast injury and cardiovascular disease progression. Huperzine A (HupA), a natural Lycopodium alkaloid, exhibits antioxidant and anti-inflammatory properties, but its cardioprotective mechanisms remain unclear. This study aimed to investigate the effects of HupA on ox...
Yu-Song Zhang, Hong-Xia Long, Li Qiao et al.· Antioxidants· 0 citations
Cryptotanshinone (CTS), a bioactive diterpenoid extracted from Salvia miltiorrhiza Bunge, has long been recognized as a traditional Chinese herbal compound. This study reveals that CTS exerts potent anti-hypertrophic effects against angiotensin II (Ang II)-induced cardiac hypertrophy by targeting Sirtuin 3 (SIRT3)-medi...
Jian-Ming Xing, Peng Ji, Xin-Tong Gu et al.· Antioxidants· 0 citations
Background/Objectives: Doxorubicin (DOX) is an effective chemotherapeutic agent whose clinical use is limited by dose-dependent cardiotoxicity that may progress to irreversible heart failure. Celastrol (Cel), a bioactive triterpenoid from Tripterygium wilfordii, has recognized anti-inflammatory and antioxidant activiti...
Yang Zhang, Jing-Yi Qi, Ming-Yang Cui et al.· Pharmaceuticals· 0 citations
SKN attenuates DOX-induced myocardial injury, senescence, and fibrosis and is associated with improved redox and mitochondrial homeostasis and suppression of p53/p21-associated senescence signaling, with DRP1-related mitochondrial dysregulation contributing to the protective effects of SKN.
BACKGROUND
Chronic stress-induced cardiac hypertrophy is often accompanied by energy metabolism within the mitochondria, iron homeostasis, and inflammation. Eugenol (Eug), as an antioxidant, scavenges reactive oxygen species (ROS) in the body and stabilizes the internal cellular environment. However, the mechanism of t...
Shi-Tao Zhao, Zhi-Cong Qiu, Lian-Fen Zhou et al.· European Journal of Pharmaco...· 0 citations
Age-associated cardiac remodeling, characterized by hypertrophy and fibrosis, is a major contributor to cardiovascular morbidity in the elderly and is often exacerbated by metabolic stressors such as hypercholesterolemia. Given the central role of mitochondrial dysfunction in these processes, we investigated whether mi...
Hridya Chempon, Sriravali Pulipaka, Altab Shaikh et al.· Biochemical and Biophysical...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
