The present review provides a comprehensive overview of potential of various delivery systems, viz., lipoplexes, liposomes, polyplexes, nanoparticles and so forth to selectively relocate foreign therapeutic DNA into liver cell type via the receptor mediated endocytosis.
This article reviews the recent progress and challenges associated with nano-based non-viral vectors designed for targeted delivery of DNA into cancerous cells.
M. Yousefian, Maryam Baharmast· Journal of Biomaterials Scie...· 0 citations
Various functionalized nanocarriers for gene delivery including silica-based nanoparticles, gold NPs, magnetic NPs, graphene-based materials, carbon nanotubes, polycationic systems, and lipidic nanostructures are summarized.
Houra Nekounam, Ali KarbalaeiMahdi, Faranak Mohammadi et al.· Nanotechnology· 0 citations
The integration of rational material design, high-throughput screening, artificial intelligence, and interdisciplinary collaboration will be essential to advance next-generation targeted in vivo mRNA cell therapies toward clinical translation.
Danyang Wang, Yumin Li, Jinfeng Deng et al.· Drug Delivery· 0 citations
Cancer immunotherapy is a transformative technology allowing for the elimination of malignant cells through immune system stimulation; however, the large-scale clinical application of adoptive cellular therapy technologies is limited due to difficulties in ex vivo immune cell engineering, high costs, and complicated ma...
Hari Krishnareddy Rachamala, Sandeep Atla, R. S. Angom· Frontiers in Pharmacology· 0 citations
Novel NCs like microemulsions, vesicular (liposomes), and nanoparticular NCs are created and explored, which have unique improved penetration and retention in the tumour tissue.
Shalu Tiwari, Abhijeet Ojha, A. Singh et al.· Journal of Drug Delivery and...· 0 citations
Liver-targeted drug delivery offers opportunities to increase therapeutic exposure at sites of hepatic disease while limiting systemic toxicity; however, successful targeting requires more than preferential accumulation of a carrier within the liver. This narrative review critically summarizes recent advances in synthe...
S. Sergazy, Roza B. Seidakhmetova, Yernur Zakirov et al.· International Journal of Mol...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
