This review systematically summarizes the structure of VDAC2, its versatile roles in mitochondrial function, disease mechanisms, and advances in pharmacological targeting, with the aim of providing a theoretical basis for VDAC2‑targeted drug development and clinical translation.
Recent studies demonstrate promising therapeutic targets for mitochondrial dysfunction and highlight the need for research in mitochondrial function to change the therapeutic landscape in the management of mitochondrial dysfunction-associated diseases.
O. A. Akinkunmi, Feyikemi Funmilayo Araba, J. A. Chukwudebelu et al.· Frontiers in Cell and Develo...· 0 citations
This review systematically summarize the specific mitochondrial pathological phenotypes in various diseases and provides a comprehensive overview of natural products that correspond to these phenotypes, along with their mechanisms of action.
Xin-Yue Liu, Hu Li, Xuekai Wang et al.· Chinese Journal of Natural M...· 0 citations
The different facets of mitochondrial quality control are explored and their implications in disease progression and aging are discussed, providing an overview of their potential to mitigate disease burden and promote healthy aging.
Agustina Creus, Shrestha Mohapatra, Leonardo Ortega et al.· Signal Transduction and Targ...· 2 citations
This review discusses the biochemical links between oxidative stress and mitochondrial dysfunction and their roles in cardiovascular disease, type 2 diabetes, neurodegeneration, metabolic liver disease, cancer, and aging, and widely used biomarkers and current therapeutic strategies.
A. Abdulkader, A. M. Hussein· World Journal of Chemical an...· 0 citations
DJ-1 is a redox-sensitive protein implicated in early-onset Parkinson’s disease, and its mitochondrial localization protects against oxidative stress, but the mechanisms regulating its submitochondrial targeting and functional impact on mitochondrial integrity remain poorly understood. We identify voltage-dependent ani...
Jéssica Taday, D. Im, S. Hewitt et al.· bioRxiv· 0 citations
Overall, this Collection positions mitochondrial biology as a mechanistic framework connecting metabolic dysfunction, cellular stress, neuroinflammation, and neuronal degeneration, and supports its development as a therapeutic target for disease-modifying interventions in neurological disorders.
Rita Valenzuela, A. I. Rodriguez-Perez· Cellular and molecular neuro...· 0 citations
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