Correlation of serum adiponectin with glycemic control and lipid profile in newly diagnosed type 2 diabetes mellitus patients

Abstract

Type 2 diabetes mellitus is a one of the leading disease had highest mortality and morbidity in worldwide, which is due to relative are absolute insulin deficiency and resistance adiponectin is a adipocytokine with primary role of regulating carbohydrate and lipid metabolism through insulin secretion and sensitivity in tissues. Therefore, it is of interest to correlate the serum adiponectin with glycemic control and lipid profile in newly diagnosed type 2 diabetes mellitus patients. This study recruited a total one hundred and twenty subjects, among this sixty type 2 diabetes mellitus and remaining were healthy controls. The fasting venous blood sample were collected for measurement of blood sugars, glycated hemoglobin and lipid profile and adiponectin levels. Serum adiponectin levels were significantly decreased in type 2 diabetes mellitus patients when compared to controls and these levels were inversely correlated with blood sugars, glycated hemoglobin, total cholesterol, triglycerides, very low-density lipoprotein and low-density lipoprotein (P=0.001**). Thus, data show that serum adiponectin might be considered a clinically relevant potential and therapeutic marker for management of blood sugars and lipid profile in newly diagnosed type 2 diabetes mellitus patients.