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Open access

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failure

I. Kocherova Muriel Giger A. Laimbacher L. Minder D. Nurzynska F. Di Meglio G. Bonazza E. Pachera Filip Rolski M. Mączewski Przemysław Leszek Michele Visentin O. Distler P. Błyszczuk G. Kania
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

Dysferlin is a stress-inducible antifibrotic regulator that limits maladaptive fibroblast differentiation and myocardial fibrosis, thereby representing a potential therapeutic target to attenuate adverse cardiac remodelling in HF.

DOI Semantic Scholar
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