TL;DR
The findings support FA-Zn-Dio-AP nanoparticles as a promising platform for controlled, colon-directed delivery of Dio and showed improved stability under thermal, pH, ionic-strength, and refrigerated storage conditions.
Diosmin (DSN) is a potent flavonoid used for chronic venous insufficiency, but its therapeutic potential is constrained by poor aqueous solubility and low oral bioavailability (BCS Class IV). To overcome these challenges, a hybrid polymeric nanocarrier system comprising poly(lactic-co-glycolic acid) (PLGA) and (2-hydro...
Resveratrol (RES), a natural compound widely used as a food additive and preservative, exhibits anti-inflammatory and antioxidant activities. However, its poor solubility and stability severely limit its translational potential for clinical applications. To address these challenges, we developed a core-shell nanopartic...
The results demonstrated the successful preparation of EA-encapsulated nanoparticles with favorable physicochemical properties, sustained release, favourable initial colloidal properties, and enhanced gastrointestinal stability, supporting their future applications in food and nutraceutical formulations.
Enhanced efficacy is attributed to the synergistic action of butyric acid as a histone deacetylase inhibitor (HDACi), which complements curcumin’s anticancer activity.
In this study, capecitabine (CAP) niosomes were prepared using the thin-film hydration method with Span 60 and cholesterol as key excipients and the formulation was optimized using a 32 factorial design. The synthesized folic acid-chitosan (FA-CS) conjugate was used to functionalize the niosome surface. An optimized fo...
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