This review traces CKDu/HSN from agricultural communities to its relevance as a nephrology and public-health priority and synthesizes biomarker and histopathologic evidence supporting a tubulointerstitial phenotype and examines how climate change is expanding heat-related kidney risk.
Preventing the growing burden of heat-related kidney injury demands urgent climate action alongside a coordinated kidney health response, with global research collaboration and integration of clinical and societal strategies targeting patient education, context-specific clinical guidance and strong policy responses add...
L. McMullen, Alexandra Gallagher, Daniel Gagnon et al.· Nature Reviews Nephrology· 0 citations
Chronic kidney disease of unknown etiology (CKDu) affects residents of distinct clusters of rural communities in Central America, Sri Lanka, and India. Affected persons may lack conventional metabolic or vascular risk factors for CKD and present with declining kidney function in the absence of significant proteinuria....
M. C. Nieves, N. Nanayakkara, Ramón García-Trabanino et al.· Nephrology, Dialysis and Tra...· 0 citations
Background: Kidney stone disease (KSD) or Nephrolithiasis is an escalating occupational health challenge in high-heat environments, including military, mining, agricultural, and construction sites. Existing evidence remains fragmented regarding how occupational heat stress interacts with lifestyle determinants and meta...
Ivan Dwi Saputro· Journal of Education Technol...· 0 citations
Objective:
Chronic kidney disease of unknown origin (CKDu) is emerging as an important public health problem in Pakistan, where conventional risk factors like diabetes and hypertension do not fully explain its rising prevalence. This review aims to analyze the multifactorial etiology of CKDu in the Pakistani context, s...
S. Imtiaz, F. Saeed, Shoukat Memon et al.· Pakistan Journal of Kidney D...· 0 citations
Chronic kidney disease (CKD) disproportionately affects people of African ancestry worldwide including those living in Europe and the United States (US), with overrepresentation among those with advanced CKD and kidney failure. This excess burden reflects the convergence of genetic susceptibility, including Apolipoprot...
A. Ramnarine, Ijeoma Uhegbu, Ezigbo Iyamah et al.· Nephrology, Dialysis and Tra...· 0 citations
A conceptual framework comprising four overlapping CKM-related kidney vulnerability domains is proposed, which may help identify individuals at increased CKD risk, support earlier screening and longitudinal monitoring, and inform preventive strategies.
M. Bozic, Marrietta Theodorakopoulou, S. Bevc et al.· Nephrology, Dialysis and Tra...· 0 citations
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