Jul 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 29 references
Medicine
TL;DR
An AS-associated hub-gene network with single-cell context is defined and convergent computational and experimental evidence that quercetin exerts endothelial-protective effects consistent with multi-target modulation of the hub-gene network is provided, supporting its therapeutic potential in AS.
A macrophage-centered anoikis-related immune signature in atherosclerosis is defined and HAVCR2 is identified, together with CD36, PLAU, TNF, PYCARD, SERPINA1, BLNK, and CHI3L1, as potential biomarkers and candidate targets for future diagnostic and therapeutic investigation.
Qiang Shen, Zheng-Feng Fan, Jin-Cheng Hou et al.· Frontiers in Immunology· 0 citations
The findings support PFKFB3 as a potential biomarker and mechanistic hub and suggest that salidroside may modulate its activity and provide a multi-layered framework connecting glycolytic remodeling, inflammatory transcriptional activity, and intercellular signaling in CHD.
Hao-Bo Yang, Yonghui Zhang, Yun-Feng Yu et al.· International Journal of Mol...· 0 citations
Integrative transcriptomics identified conserved central-peripheral signatures in PD and five hub genes are candidate biomarkers/therapeutic targets, offering a systems-level framework for disease mechanisms and independent cohort validation.
Ehsan Lotfi, Arsh Ketabforoush, Fereshteh Azeditehrani et al.· Bioinformatics and Biology I...· 0 citations
The GO and pathway enrichment analysis results revealed that the up regulated genes were mainly enriched in response to stimulus, cytoplasm, small molecule binding and signal transduction, whereas down regulated genes were mainly enriched in multicellular organism development, cell junction, ion binding and cardiac con...
B. Vastrad, Shivaling Pattanashetti, C. Vastrad· Ageing International· 0 citations
These results nominate CLEC4A and P2RY13 as candidate genes potentially involved in shared APS–CAS immune-related pathways, with expression changes associated with CAS progression among APS patients.
Jixiang Pei, Chao Huang, Haoran Wan et al.· PeerJ· 0 citations
The present investigation successfully pinpointed five critical genes alongside one key cellular population, collectively providing potential molecular insights and candidate targets for further investigation into AS calcification.
