Mitochondria-mediated anticancer effects of two previously characterized COX-2 inhibitors in hepatocellular carcinoma

p-Coumaric acid inhibits hepatocellular carcinoma through promoting ROS accumulation

Mdivi-1 augments chlorpromazine’s anticancer effect via modulation of mitochondrial dynamics, hallmarks of cancer-related cellular behavior, and oxidative stress

Effects of a Benzimidazolium Salt on Colorectal Cancer Cells: Involvement of Apoptosis and Autophagy

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel small molecules capable of targeting multiple survival pathways. In this study, the antiproliferative potential of dds benzimidazole-palladium (Pd) complexes was evaluated across breast cance...

Baicalein Exerts Cytotoxic Effects Through Cell Cycle Arrest and Mitochondria- Dependent Pathway in Ovarian Cancer Cells: In-Vitro and Computational Evaluation.

Findings showed that baicalein induces apoptosis in ovarian cancer PA-1 cells via a ROSmediated, mitochondria-dependent pathway and highlights the potential of baicalein as a promising lead compound for the development of anticancer therapeutics.

A Novel Indole-Dihydroisoxazole Compound Activates Apoptotic, Mitochondrial and Autophagy-related Responses in Lymphoid and Myeloid Leukemia Cells.

Findings highlight the therapeutic potential of isoxazole-derived compounds, particularly DHI1, warranting further investigation in additional preclinical models and provide valuable insights into the molecular mechanisms underlying the antiproliferative effects of DHI1.

Preclinical Evaluation of Labetalol for Cutaneous Melanoma Drug Repurposing: Cytotoxic Activity in A375 Cells and Mitochondria-Associated Apoptotic Signaling

LB displayed concentration-dependent in vitro cytotoxicity in A375 melanoma cells, whereas HaCaT keratinocytes showed limited changes under the investigated conditions, providing preliminary evidence supporting further investigation of LB within a melanoma-directed drug-repurposing strategy.