Sep 2026· JACC Case Reports· pp.
110532
· 0 citations· 9 references
Medicine
TL;DR
The feasibility of TTVR in elderly patients with complex anatomy is demonstrated and effective in selected elderly high-risk patients with severe TR and challenging anatomy and delayed conduction disturbances as a clinically important complication requiring extended rhythm surveillance are highlighted.
Abstract
Background
Severe tricuspid regurgitation (TR) is associated with substantial morbidity and mortality and remains undertreated in elderly patients with prohibitive surgical risk. Transcatheter tricuspid valve replacement (TTVR) has emerged as a therapeutic option for anatomies unsuitable for transcatheter edge-to-edge repair.
CASE SUMMARY
We report 2 elderly high-risk patients with torrential symptomatic TR who underwent orthotopic TTVR using transfemoral venous access. The first patient, a 94-year-old woman with prior mitral annuloplasty and a transvalvular pacemaker lead, underwent successful TTVR with complete elimination of TR and rapid symptomatic improvement. The second patient, an 84-year-old man with severe leaflet tethering and complex anatomy, underwent successful valve implantation but subsequently developed delayed complete atrioventricular block requiring leadless pacemaker implantation.
Discussion
These cases demonstrate the feasibility of TTVR in elderly patients with complex anatomy and highlight delayed conduction disturbances as a clinically important complication requiring extended rhythm surveillance.
TAKE-HOME MESSAGES
TTVR is feasible and effective in selected elderly high-risk patients with severe TR and challenging anatomy. Delayed conduction abnormalities may occur several days after implantation and warrant structured rhythm monitoring.
Background Severe tricuspid regurgitation (TR) carries high morbidity and is often undertreated in patients with complex congenital heart disease and prohibitive surgical risk. Case Summary A 33-year-old woman with complex congenital heart disease and multiple prior surgeries presented with progressive right-sided hear...
Emily Morris, Ali B. Roomi, M. Costello et al.· JACC Case Reports· 0 citations
Background Transcatheter edge-to-edge repair has emerged as a minimally invasive option for patients at high surgical risk. Residual/recurrent tricuspid regurgitation (TR) is associated with high morbidity and mortality. Case Summary A 79-year-old woman developed recurrent severe TR after initially successful TriClip i...
A. Winkler, Katja Gansterer, E. Boxhammer et al.· JACC Case Reports· 0 citations
BACKGROUND
Cor triatriatum sinistrum (CTS) is a rare congenital malformation, and its coexistence with degenerative mitral regurgitation (MR) in older adults is exceptionally rare and creates substantial technical challenges for transcatheter interventions.
CASE SUMMARY
We report a 78-year-old woman presenting with p...
Shi-Cheng Li, Yu-Bao Hu, Jie Shen et al.· JACC Case Reports· 0 citations
Background Concomitant aortic and mitral regurgitation (CAMR) is a rare valvulopathy, seen in patients with scoliosis, and rarely involves aortic regurgitation with concomitant primary mitral regurgitation associated with poor prognosis when left untreated. Current guidelines lack robust evidence to guide the managemen...
Dominador V. del Castillo, Bin Wang, Yan Wang· JACC Case Reports· 0 citations
TTVR with both, the Cardiovalve and EVOQUE prothesis is an effective treatment option, leading to profound TR reduction and meaningful clinical improvement at 30-day follow-up.
Florian Genske, Judith Heine, C. Marquetand et al.· Frontiers in Cardiovascular...· 0 citations
Abstract Background Transcatheter tricuspid valve replacement (TTVR) is an option for selected patients with severe tricuspid regurgitation (TR) who are at high surgical risk, but experience remains limited in those with extreme right-heart anatomy, including a giant right atrium and a markedly enlarged elliptical tric...
Qun-Tai Qiu, Xin-Lei Wu, Dao-Zhu Wu et al.· European Heart Journal: Case...· 0 citations
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