Review
Open access
Efficacy and Safety of Mechanical Insufflation–Exsufflation in Invasively Ventilated Critically Ill Adults: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Medicine
Abstract
Mechanical insufflation–exsufflation (MI–E) is increasingly used in invasively ventilated adults in the intensive care unit (ICU), yet its therapeutic efficacy and safety remain uncertain due to inconsistent evidence.