Skip to content
Log in
Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Transcriptomic network analysis and functional evidence identify a candidate EMT hub signature associated with nasopharyngeal carcinoma progression.

Xiao-Peng Sun Bo Kou
Jul 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 50 references
Medicine

TL;DR

Integrative analysis identifies VIM, SNAI1, ZEB1, and FN1 as a candidate EMT-associated hub signature linked with NPC progression, prognosis, and drug response patterns, suggesting that this EMT hub network may have potential value as a prognostic biomarker panel and as a putative therapeutic vulnerability requiring further validation.

DOI PubMed Semantic Scholar
View source

Similar papers

Sep 2026

Identification of a metastasis-associated prognostic gene signature in osteosarcoma through integrated bioinformatics and functional analysis

This integrated computational and experimental study identifies AURKB, CDC20, KIF11, and TOP2A as key oncogenic drivers in osteosarcoma, with significant diagnostic, prognostic, and therapeutic implications.

Qingquan Xia, Xiangchao Meng, Xu-Hua Wu et al. · 0 citations
Open access Aug 2026

TPD52 promotes breast cancer cell migration, invasion and proliferation via activation of the MAPK/ERK signaling pathway

Elevated TPD52 expression was associated with longer overall survival in specific subgroups, including the basal-like subtype, invasive lobular carcinoma, and N0/N1 stages, and a random forest-based diagnostic model demonstrated high accuracy across multiple datasets.

J. Yu, Z. Zhu, R. Deng et al. · 0 citations
Aug 2026

Resveratrol Modulates Lung Cancer-Associated Hub Genes Identified by Integrated Bioinformatics, Single-Cell Analysis, Molecular Docking, and Experimental Validation

This study identified five lung cancer-associated hub genes and provided preliminary evidence that resveratrol may modulate their expression, and provides a multi-level molecular framework for further investigation of resveratrol-responsive networks in lung cancer.

Jing-Hua Yang, Han-Xiu Wei, Jie Li et al. · 0 citations
Open access Aug 2026

Integrative transcriptomic and experimental analysis identifies GREM1 as a pro-metastatic mediator in lung adenocarcinoma

Mechanistically, GREM1 interacts with BMP2 and induces epithelial–mesenchymal transition and glycolysis via the TGF-β signaling pathway, thereby promoting LUAD progression and metastasis, and emerges as both a metastasis driver and therapeutic target.

Zhen-Qing Li, Hui-Rong Huang, Ke-Rong Zhai et al. · 0 citations
Open access Sep 2026

Network based approach identifies miR-145-3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma.

In MTC cells, simultaneous inhibition of miR-145-3p together with its top co-expressed miRNAs increased proliferation and survival, and enhanced ERK phosphorylation, indicating MAPK pathway activation and a shift toward a more aggressive phenotype.

A. Citarella, Manuela Petti, Z. M. Besharat et al. · 0 citations
Open access Jan 2026

Integrative Pan‐Cancer Characterization of lncRNA UPK1A‐AS1 and Its Role in Hypoxia‐Associated Sorafenib Resistance in Hepatocellular Carcinoma

It is suggested that UPK1A-AS1 is a hypoxia‐inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type‐dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia‐associated drug resistance in HCC.

Ze-Kai Li, Min Luo, Shu-Sen Fang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.