Direct voltage imaging reveals ongoing and spatially coordinated electrical activity within intact peripheral sensory arbors within trigeminal neurons in vivo, providing access to the generation and integration of neuronal output within fine axonal compartments in vivo.
It is demonstrated that TG and DRG neurons differ not only in individual electrophysiological properties but also in the coordinated organization of those properties, indicating that coordinated regulation of excitability differs between sensory ganglia.
Sachin Goyal, Nesia A. Zurek, Sascha R. A. Alles· eNeuro· 0 citations
Low-intensity ultrasound alters neuronal excitability long after exposure ends, but the basis of this offline effect is unclear and most proposed mechanisms require synaptic receptors. We recorded from cultured mouse hippocampal neurons in whole-cell current clamp, before and 20 min after 1 min of 850 kHz continuous-wa...
M. Stippinger, Édua Édes, Barnabás Kovács et al.· bioRxiv· 0 citations
A stochastic two-compartment Hodgkin–Huxley type model is developed, consisting of a soma and an axon initial segment, to investigate the effects of synaptic noise and intrinsic electrical properties of spPVINs in driving their spontaneous firing and demonstrate how intrinsic electrical properties of spPVINs shape thei...
Rian Fritz D. Jalandoni, Christopher Todrineau, Hao-Yi Qiu et al.· bioRxiv· 0 citations
To understand neural computations, one would like to relate circuit dynamics to neuronal intrinsic excitability and connectivity. We developed tools for large-scale all-optical electrophysiology and applied them to approximately 300 layer 1 interneurons per mouse in vivo. Across two mice, targeted stimulation and volta...
Yitong Ǫi, Vicente J. Parot, Xiang Wu et al.· bioRxiv· 0 citations
Neuromodulation of peripheral nerves via implanted devices produces relief from chronic pain in some patients, but rarely fully eliminates pain. Electrical stimulation lacks selectivity (e.g., between afferent and efferent fibers) to activate only the target Aα/Aβ-fiber axons and must have the stimulating current...
Mary G. Ardren, Benjamin Wrobel, Jerico V. Matarazzo et al.· BMC Neuroscience· 0 citations
ABSTRACT
In vivo fiber photometry has become an effective approach for quantifying nociceptive state dynamics in defined neural populations across the brain and spinal cord (ie, neuraxis) in rodent models. By enabling longitudinal recordings with cell-type specificity during freely moving behavior, photometry is well-s...
M. H. Miah, Gao-Zhen G. Li, Srishti Bose et al.· Pain· 1 citation
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