Aug 2026· Journal of Pharmaceutical Innovation· Vol 22· 0 citations· 49 references
TL;DR
Overall, the developed multi-polymeric sub-micron microsphere system represents a promising strategy for improving valsartan solubility, stability, and sustained oral delivery, with potential to enhance therapeutic efficacy and patient compliance.
Lamotrigine-loaded chitosan-sodium alginate polymeric nanoparticle system optimized by BoxBehnken Design demonstrated improved release control, enhanced pharmacokinetic parameters, and superior anticonvulsant activity in vivo, supporting their potential as a sustained-release system for epilepsy management.
D. R, J. B., K. M et al.· Drug Delivery Letters· 0 citations
The developed chitosan-coated Eudragit® S100 nanoparticle system represents a promising platform for sustained, colon-targeted oral delivery of HSP and other poorly bioavailable bioactive compounds.
Background/Objectives: Solid self-nanoemulsifying drug delivery systems (SNEDDS) prepared by adsorption onto porous carriers are widely used to improve the oral delivery of poorly water-soluble drugs. However, this approach is limited by increased dosing volume and incomplete drug release. This study aims to develop a...
Abdelrahman Y. Sherif, Mohammad A. Altamimi, E. Elzayat· Pharmaceutics· 0 citations
Oxiconazole nitrate-loaded nanospheres were successfully developed using the emulsification–solvent evaporation method to enhance the solubility and dissolution of oxiconazole nitrate, a Biopharmaceutics Classification System (BCS) Class II antifungal drug characterized by low aqueous solubility and good membrane perme...
Suyash Shashikant Ingle, A. Chavan, Vasundhara Somnath Patil et al.· International Journal of Sci...· 0 citations
Atorvastatin calcium, a widely prescribed HMG-CoA reductase inhibitor used in the management of hypercholesterolemia and dyslipidaemia, belongs to BCS Class II, characterized by low aqueous solubility and consequently poor and variable oral bioavailability (approximately 12–14%). This limitation arises primarily from p...
R. Gandhi, V. Gunaseelan, M. Prakash et al.· IJPAR JOURNAL· 0 citations
INTRODUCTION/OBJECTIVE
Niosomes are nonionic surfactant-based vesicular systems. Paliperidone, which is an atypical antipsychotic used in the management of schizophrenia, exhibits poor aqueous solubility and limited oral bioavailability, which could limit its therapeutic effectiveness. This study aimed to develop and o...
Ayam Ayad, Khalid K. Al-kinani· Recent Advances in Drug Deli...· 0 citations
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