TL;DR
Hydrodynamic shear and medium ionic strength jointly influence ASD supersaturation and precipitation behavior and their simultaneous consideration may improve the biorelevance of ASD dissolution testing.
The solid dispersion of ABA with HPMCAS-LF significantly improved solubility, dissolution, and diffusion, highlighting its potential for enhanced oral bioavailability and improved therapeutic outcomes.
A thermoresponsive solid dispersion containing atorvastatin calcium enhances dissolution performance and eliminates the need for organic solvents through simple manufacturing processes.
The findings indicate that the dissolution performance of CL/PVP-K30-based ASDs is governed by the balance between the amorphization and the dissolution retarding effects of polymer hydration, highlighting the importance of polymer selection for optimizing HME formulations of poorly water-soluble drugs.
The phenomenological Jouyban-Acree model combined with statistical simulation minimizes the volume of routine testing and reliably predicts the stability of systems during their industrial scale-up.
It is expected that the in vivo performance of these ternary ASDs would be determined by the interplay between the enhanced release rate and the decreased permeation rate of the drug.
EASD could serve as a desirable carrier to provoke the biopharmaceutical and pharmacokinetic properties of ITZ and suggested that EASD could serve as a desirable carrier to provoke the biopharmaceutical and pharmacokinetic properties of ITZ.
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