Aug 2026· Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology· Vol 20, pp. 256 - 274· 0 citations· 120 references
TL;DR
This review characterizes the properties of two-pore channels and describes their regulation by phosphatidylinositol-3,5-bisphosphate and NAADP, changes in channel activity during cell starvation, as well as the effects on TPC channels exerted by sphingosine, protein kinases P38 and JNK, and regulatory proteins mTor, Rab7a, and Tmem63a.
A comprehensive understanding of functional interactions of TMEM16A channels may provide new insights into the physiological and pathological roles of TMEM16A ClCa channels and may facilitate the development of novel therapeutic strategies for TMEM16A-associated diseases.
H. Yamamura, Rubii Kondo, Yoshiaki Suzuki et al.· Journal of Physiology· 0 citations
Sodium-proton exchangers (NHEs) are found in all cells to regulate intracellular pH, sodium levels and cell volume. In humans, there are nine different NHE transporters (SLC9A1-9), which vary in tissue distribution, kinetics and regulation. NHE6 localizes to endosomal membranes and mutations in the protein are known to...
Suk-Han Jung, Hyunku Yeo, Hang Li et al.· Nature Communications· 1 citation
A comprehensive overview of the post-translational modifications that modulate the function, stability, and intracellular localization of NKA is provided to provide a comprehensive overview of the intricate interplay between different PTMs of NKA.
Jia Tong, Liu-Yang Qin, Yun-Ge Zhang et al.· Frontiers in Cell and Develo...· 0 citations
How LRRK2-dependent trafficking mechanisms regulate key components of synaptic transmission, including glutamatergic and GABAergic receptors, as well as astrocytic transporters are examined, highlighting how disruption of these processes affects neurotransmitter clearance, receptor activation, and ultimately E/I balanc...
Angela Di Iacovo, C. D'Agostino, Giulia Casoli et al.· Cellular and molecular neuro...· 0 citations
This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.
Shuo Han, R. Duan, Sarah Applewhite et al.· bioRxiv· 0 citations
Results suggest that the modulation of PKA activity and GPR81 signaling may regulate lactate transport via MCT1, thereby ensuring its proper metabolic function in podocytes.
Klaudia Grochowalska, Maria Szrejder, Irena Audzeyenka et al.· International Journal of Mol...· 0 citations
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