Jul 2026· Current pharmaceutical design· Vol 32· 0 citations
Medicine
TL;DR
The observed effects indicate that CCl4-induced liver injury is accompanied by broad CYP450 dysregulation, and that Ns and TQ provide significant protection by restoring enzymatic balance and mitochondrial function.
It is indicated that combining papaya, neem, and garlic extracts may provide greater hepatoprotection than administering the individual extracts against DEN-induced liver injury, and supports further mechanistic and preclinical evaluation of this polyherbal formulation before its potential therapeutic application in li...
Egeonu Us, Umaru I. J., Izam Ed et al.· African Journal of Clinical...· 0 citations
Cinnamic acid may exert hepatoprotective effects against CCl₄-induced liver injury, with secondary favorable effects on renal biochemical markers of CCl₄-induced systemic toxicity, by modulating oxidative and inflammatory pathways.
The methanolic extract of Cyamopsis tetragonoloba methanolic extract showed considerable hepatoprotective action against CCl₄-induced liver damage, as shown by normalised biochemical indicators and improved liver histology.
Priyanka Singh, B. T, H. Joshi et al.· Adolescência e Saúde· 0 citations
The liver is the principal site of drug metabolism and biotransformation and is therefore vulnerable to toxic injury by xenobiotics. Paracetamol (PCM) is one of the most frequently used analgesic and antipyretic agents; however, excessive or prolonged use is associated with severe hepatic damage caused by the formation...
Intisar Ahmed Yusif· Al-Turath Medical Journal· 0 citations
The biochemical and histopathological findings collectively support the traditional medicinal use of this plant for liver protection and suggest its potential as a natural hepatoprotective agent.
Nisha Chandila, Suresh Kumar, Manoj Kashyap· The International Journal of...· 0 citations
Interestingly, the LYP co-administration abrogated the CPM-induced oxidative stress, proinflammation, apoptosis, and DNA fragmentation and indicates that LYP supplementation may protect the kidney from oxidative stress-related attacks of CPM.
Nourah Almulhim, Manal Alfuwaire, H. Elsawy et al.· Avicenna Journal of Phytomed...· 0 citations
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