2026· Advances in Immunology· Vol 171, pp.
283-306
· 0 citations
Medicine
TL;DR
This chapter provides a comprehensive synthesis of microglial biology across multiple interfaces, including transcriptomic, lipid-associated metabolic, cell senescence, and metabolic reprogramming, and positions microglia biology as a metabolically plastic, spatially organized immune-regulated microenvironment that can efficiently aid in reprogramming and AD therapeutics.
This review systematically outlines the fundamental characteristics of microglial glucose metabolism and focuses on how the dynamic metabolic reprogramming it undergoes during AD progression regulates microglial immune behavior and inflammatory responses.
Qing-Yu Cao, Meng-Meng Shen, Yan Liu et al.· Journal of Alzheimer's Disea...· 0 citations
It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.
Donghoon Lee, James M. Vicari, Christian Porras et al.· Nature Genetics· 1 citation
This chapter focuses on the diversification of neurodegenerative CNS microglial states, the interaction of microglia with neurons, glial cells, adaptive immune cells, and the vasculature, and how this framework provides a basis for therapeutic strategies aimed at modulating, replacing, or reprogramming microglia in neu...
Hao Huang, E. Mass· Advances in Immunology· 0 citations
A “cellular state–pathological network–therapeutic window” framework is proposed and the roles of microglia in amyloid-β plaque seeding and compaction, NLRP3 inflammasome activation, mitochondrial DNA–cGAS–STING signaling, complement-mediated synaptic engulfment, and bidirectional microglia–tau feedback are systematica...
Lian-Jing Xu, Ying Zhang, Li Jiang et al.· Frontiers in Cellular Neuros...· 0 citations
A distinct microglial state is identified that provides new insights into the dynamic role of microglia in AD and is associated with the phagocytosis of dystrophic neurites and was recapitulated in vitro using an efferocytosis-based model.
W. Cai, Xiaoli Pan, T. Qian et al.· Neuroscience Bulletin· 0 citations
This work situates MiET formation within the broader microglial functional repertoire and focuses on how ET-dominant responses may compromise homeostatic or neuroprotective roles, expanding the conceptual framework for microglial pathogenicity and inviting future mechanistic and translational research.
Lipika Sha, Sushmita Jha· Advances in Immunology· 0 citations
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