Aug 2026· Advanced Functional Materials· 0 citations· 23 references
Abstract
Gold nanoparticles (AuNPs) exhibit size‐ and shape‐dependent physicochemical properties, yet precise morphological control under environmentally benign conditions remains challenging due to the lack of spatial regulation of nucleation and growth. Here, we explore liposome‐based nanoreactors as confined reaction fields for peptide‐mediated synthesis of AuNP. Unexpectedly, biomineralization peptides that form anisotropic and faceted nanostructures in bulk solution produce distinct morphologies within liposomes, yielding highly branched Au/liposome hybrid structures. This discrepancy originates from peptide sequence–dependent spatial localization within liposomes. Peptides localized at the membrane interface induce interfacial growth, whereas internally confined peptides promote nucleation within a diffusion‐restricted environment, resulting in spherical nanoparticles. Modulation of membrane composition enables switching of peptide localization, confirming that spatial positioning governs nanoparticle growth. These findings demonstrate that peptide localization acts as a molecular switch governing nanoparticle growth within liposomal nanoreactors.
Lipid‐coated hybrid nanoparticles represent a promising platform for biomedical applications, offering enhanced stability, biocompatibility, and functional tunability. However, the molecular‐level organization of lipids on nanoparticle surfaces remains poorly understood. Here, we employ atomistic molecular dynamics sim...
Kalpani A. Mirihana, Rashad Kariuki, Charlotte E. Conn et al.· Advanced Materials Interface...· 0 citations
Biological systems often regulate catalysis by organizing enzymes within dense, multivalent, and nanostructured environments. Nanomaterials can recreate selected features of these environments, but their effects on enzymes range from inhibition to activity enhancement depending on the chemistry of their surface ligands...
Gabriel Gilman, Atri Bhattacharya, Niloufar Yavari et al.· ACS Applied Materials and In...· 0 citations
Chiral gold nanoparticles exhibit unique chiroptical properties, but their integration into plasmonic devices requires an understanding of the formation of chiral features and controlling their growth on substrates. Here, we combine microfluidic synthesis and liquid-phase transmission electron microscopy (LP-TEM) to...
Marta Zarzuela-Amor, Martina Lonza, Gail A. Vinnacombe-Willson et al.· Nano letters (Print)· 0 citations
Gold nanoparticle-based vesicular nanostructures are attractive drug delivery platforms because of their tunable plasmonic properties; however, simultaneously achieving efficient cargo encapsulation, robust aqueous stability, and controllable near-infrared (NIR)-triggered release remains challenging. Herein, water-disp...
Precise control over the self-assembly pathways of anisotropic nanoparticles into supercrystals is essential for constructing functional nanodevices and metamaterials with tailored superstructures. However, the crystallization of nanoparticle systems via the conventional electrostatic screening method usually leads t...
The controlled aggregation of plasmonic nanoparticles remains a critical challenge for achieving temporally stable and reproducible colloidal substrates for surface-enhanced Raman scattering (SERS). Here, we show that the antihistamine drug bilastine induces a concentration-dependent, self-limiting aggregation of citra...
Maelly A. Oliveira, R. A. Ando· Langmuir· 0 citations
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