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#gene editing Open access Aug 2026

Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs

Lipid nanoparticles (LNPs) are the most advanced non-viral platform for hepatic mRNA delivery, yet the functional role of helper phospholipids, particularly under repeated dosing regimens required for chronic protein replacement therapies, remains poorly understood. Here, we systematically investigated six helper phosp...

Jia-Hao Ge, Xiaochen Bo, Xinye Zhu et al. · 1 citation
Open access Sep 2026

Phosphatidylserine-Engineered Lipid Nanoparticles Enable Systemic mRNA Delivery to the Central Nervous System

Intravenously administered lipid nanoparticles (LNPs) predominantly accumulate in the liver, limiting mRNA delivery to extrahepatic tissues, particularly the central nervous system (CNS). Here, we report a ligand-free strategy for systemic CNS delivery using phosphatidylserine (PS, 1 mol %)-engineered LNPs, in which...

J. Hong, Jae Hoon Kim, Seung-Yeul Lee et al. · 0 citations
Open access Oct 2026

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery.

Pulmonary delivery of lipid nanoparticles (LNPs) remains an area of significant interest, given the broad range of genetic disorders that could be addressed through localized administration of therapeutic nucleic acids to the lung. In this study, we investigated how incorporation of the clinically used lung surfactant...

Sarah S. Nasr, Owen E. Tabah, Sahana Kumar et al. · 0 citations
Sep 2026

Optimization of lipid nanoparticle components and microfluidic parameters for intramuscular circRNA delivery with reduced hepatic off-targeting.

Circular RNA (circRNA) represents a promising class of RNAs for sustained protein expression and vaccine applications. However, current lipid nanoparticle (LNP) platforms remain poorly optimized for efficient intramuscular circRNA delivery, as they are primarily designed for the delivery of small interfering RNA and li...

Jie Yang, Yi-Jia Hao, Si-Ying Long et al. · 0 citations
Open access Sep 2026

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver.

Lipid nanoparticles (LNPs) preferentially accumulate in the liver, but hepatic tropism alone does not ensure productive RNA interference. Here, we screened a library of LNPs in which lipid composition was varied to generate distinct protein corona identities and identify formulations capable of combining liver accumula...

N. G. Sukubo, Serena Renzi, M. Violatto et al. · 0 citations
Open access Sep 2026

Tailoring lipid nanoparticles for application-specific mRNA delivery.

This study proposes an application-oriented re-engineering strategy that leverages the clinically validated SM-102 platform, enabling rational LNP optimization for diverse mRNA delivery and therapeutic scenarios and recommends SM-102/DSPC and SM-102/DOPE LNPs as preferred formulations for RAW 264.7 macrophages and IGRO...

Xin-Xin Yan, Li-Xin Lin, Yi-Fan Zhang et al. · 0 citations

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