Clinically, reduced SOCS3 expression has been associated with lymph node metastasis, advanced TNM stage, and poorer prognosis, whereas higher SOCS3 levels may correlate with improved outcomes and chemosensitivity, and further translational studies are needed to validate SOCS3 as a biomarker and therapeutic target in CRC.
Increasing clinical evidence indicates that elevated TWIST1 expression is associated with poor clinical outcomes, higher metastatic burden, and reduced treatment efficacy, emphasizing its importance as a prognostic biomarker and a potential therapeutic target in breast cancer management.
K. Saleh, R. S., P. Nayak et al.· Mutation research. Reviews i...· 0 citations
This review provides a comprehensive overview of the current understanding of lncRNA-mediated regulation of EMT and metastasis in gastric cancer and provides insights into the complex regulatory networks governed by lncRNAs, highlighting their translational potential in improving GC management.
M. Saadh, A. K. Bishoyi, R. Roopashree et al.· Biochemistry and Biophysics...· 0 citations
MiR-770 has been introduced as a potential marker in the prognosis of various cancers as well as in the early identification of tumor formation, progression, and metastasis.
Key signaling pathways and emerging mechanisms in HCC and their roles in disease development and treatment are reviewed to lead to novel therapeutic targets and the development of more effective, personalized treatment strategies.
R. Srivastava, Pratibha Singh, D. Lonard· Biomedicines· 0 citations
The JAK/STAT signaling pathway regulates processes such as proliferation, differentiation, survival, and immune responses and is strongly correlated with the initiation and progression of several malignancies in humans.
Mariyam Rafi, U. Aiman, S. M. A. Shahid et al.· Current Cancer Therapy Revie...· 0 citations
The present review summarizes the latest research on the structure of ELK3 and its regulation in normal and tumor tissues, focusing on its primary functions in tumors and the signaling pathways involved.
Zhen-Zhe Liu, Zhong Wei, Zhen-Sheng Li et al.· Oncology Letters· 0 citations
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