Petroselinic acid: a rare fatty acid with emerging roles in nutrition, green chemistry and bio-industry

Abstract

Petroselinic acid (PeA), a rare monounsaturated fatty acid (C18:1Δ6), has garnered scientific interest due to its unique cis-Δ6 double bond configuration and limited botanical distribution. Predominantly found in the Apiaceae family (e.g., parsley, coriander, dill), PeA exhibits distinct physicochemical traits such as enhanced oxidative stability, polymorphic control favoring β′ crystals, and amphiphilic interfacial behavior. These properties render it valuable in food, cosmetic, pharmaceutical, and oleochemical industries. This review comprehensively explores PeA’s biosynthesis, emphasizing acyl-ACP pathways and metabolic engineering strategies to enhance accumulation in plants and microbes. Various extraction methods, including green alternatives such as ultrasound-assisted and supercritical CO₂ extraction, are evaluated for efficiency and sustainability. PeA undergoes selective chemical transformations (e.g., epoxidation, ozonolysis) and enzymatic modifications, facilitating its application in surfactants, polymers, and bio-based lubricants. Functionally, PeA supports structured emulsions, improves product stability, and promotes health benefits, including anti-inflammatory, antimicrobial, and metabolic regulatory effects. Challenges in biosynthetic yield, industrial scalability, and bioavailability are also discussed. Ultimately, PeA emerges as a promising bioactive lipid, with future potential dependent on integrated efforts in green chemistry, biotechnology, and health research. The unique Δ6-double bond gives PeA a distinct structure and functional properties. PeA-rich oils show strong oxidative stability and β′-crystal polymorphism. Green extractions optimize PeA yield with minimal environmental impact. PeA exhibits anti-inflammatory, antimicrobial, and metabolic health benefits. Bioengineering advances enhance PeA production in plants and microbes.