Imaging insights into temporal lobe epilepsy: an AES-SDM meta-analysis and retrospective cohort study

Hippocampal microstructural alterations in temporal lobe epilepsy with hippocampal sclerosis assessed using diffusion kurtosis imaging.

Ventral anterior thalamic dysfunction distinguishes seizure generalization in temporal lobe epilepsy.

Initial evidence is provided that intra-thalamic functional connectivity, particularly within the bilateral VA complex, is associated with FBTCS history in TLE and varies with lateralization of seizureonset, and may represent a biomarker for FBTCS.

Subtle Hippocampal Subfield Volumetric Alterations in Clinically Diagnosed MRI-Negative Temporal Lobe Epilepsy.

It is implied that selective CA4-DG atrophy is a defining characteristic of the MRI-negative TLE phenotype, thereby corroborating the "dentate gate" failure hypothesis and providing a crucial diagnostic tool in settings with limited resources, where advanced techniques like 3-T MRI or invasive monitoring are not access...

Distinct Theta-gamma network reorganization differentiates hippocampal sclerosis and MRI-negative mesial temporal lobe epilepsy.

Electrophysiological evidence provides electrophysiological evidence to support precise subtyping of MTLE and targeted cognitive intervention development and suggests patients with MTLE share a common alteration in occipital-to-temporal information transfer during VWM.

Topographic-prognostic gradients of cortical hypometabolism in temporal lobe epilepsy

A hypometabolic gradient is identified in TLE, which covaries with cytoarchitectonic organization, microstructural changes, and hippocampal-neocortical interactions and provides a biologically grounded framework for precise surgical planning, emphasizing that targeting severe hypometabolism may optimize prognosis.

Diffusion Tensor Imaging as a Preliminary Study of White Matter Associations with Surgical Outcome in Mesial Temporal Lobe Epilepsy

It is demonstrated that diffusion-based structural connectivity analysis can distinguish seizure-free from non–seizure-free TLE patients, highlighting the clinical relevance of hippocampus–temporal pole and hippocampus–thalamus pathways in postoperative outcomes.