Efficacy and Safety of Tirzepatide Versus Dulaglutide in Type 2 Diabetes With or Without Established Atherosclerotic Cardiovascular Disease: A Network Meta‐Analysis of Randomized Clinical Trials
This network meta‐analysis addresses the limited dose‐specific comparative evidence by evaluating different doses of tirzepatide (TZP) versus dulaglutide (DULA) for glycemic control, weight loss, and safety in type 2 diabetes mellitus (T2DM).
Background and aims: Dapagliflozin and empagliflozin are established therapy for chronic heart failure across the ejection-fraction spectrum. Their pivotal trials were powered for a composite of cardiovascular death and worsening heart failure
Nawaf AM Alharbi, Abdullah Ahmed Alfllaj, Mohamed Ghaith et al.· International Journal of Dru...· 0 citations
Cardiometabolic disorders such as type 2 diabetes mellitus (T2DM), obesity and cardiovascular disease (CVD) remain major global health challenges. Incretin‐based therapies, including the GLP‐1 receptor agonists semaglutide and liraglutide, and the dual GIP/GLP‐1 receptor agonist tirzepatide, are increasingly used to ad...
H. Bawadi, Haya Abuhijleh, Mamon Nofal et al.· Endocrinology, Diabetes & Me...· 0 citations
To evaluate changes in glycaemic control following semaglutide discontinuation in adults with Type 1 diabetes and obesity who completed the ADJUST‐T1D randomised controlled trial.
Eslam Montaser, K. Bhasin, Davida F. Kruger et al.· Diabetes, obesity and metabo...· 0 citations
of Evogliptin for Intra-Class Therapeutic Interchange in Patients With Type 2 Diabetes Mellitus: Subgroup Analysis From a Multi-Center, Prospective, Observational Study (REVISE Study)”
Jie-Eun Lee, Jun Hwa Hong, Min Soo Song et al.· Endocrinology, Diabetes & Me...· 0 citations
Background: SGLT2 inhibitors have transformed heart failure treatment, especially empagliflozin and dapagliflozin. Although both have proven cardiovascular benefits in clinical trials, there is little data comparing them in real-world settings. This study aims to address that by comparing their effects on heart functio...
C. Bhargava, M. Daisy, Joyce Sharon et al.· International Journal of Dru...· 0 citations