Skip to content

The BDNF-mediated association between NGAL and cognitive function in drug-naïve schizophrenia

Sep 2026 · Journal of neural transmission · Vol 133, pp. 2787 - 2798 · 0 citations · 71 references
Medicine

TL;DR

A significant BDNF-mediated pathway was identified in the association between NGAL and cognitive function and in patients with DNS, those with SCI exhibited lower plasma levels of NGAL, BDNF and EGF.

View source

Similar papers

Open access Sep 2026

563. Plasma interleukin-6 levels in antipsychotic-responsive and treatment-resistant schizophrenia in association with clozapine treatment

Abstract Background Neuroinflammation has been proposed as a key pathophysiological mechanism underlying treatment-resistant schizophrenia (TRS). Interleukin-6 (IL-6) has been reported as a trait-related inflammatory marker in schizophrenia; however, data focusing specifically on TRS and the impact of clozapine treatme...

Y. Suzuki, K. Endo, S. Yokokawa et al. · 0 citations
Oct 2026

Plasma interleukin-6 levels and treatment responses to antipsychotics in schizophrenia: Focus on clozapine treatment.

Neuroinflammation is a key pathophysiological mechanism underlying treatment-resistant schizophrenia (TRS). Interleukin (IL)-6 is a trait-related biomarker that exhibits consistently elevated levels in schizophrenia. However, studies focusing on TRS and examining the associations of clozapine treatment with inflammator...

Yuhei Suzuki, Kota Endo, Shuuho Yokokawa et al. · 0 citations
Open access Sep 2026

Neuropsychiatric and neurocognitive outcomes of metformin versus insulin therapy in Egyptian patients with type 2 diabetes: focus on NGF and BDNF; a cross-sectional study

Type 2 diabetes mellitus (T2DM) and antidiabetic therapy may influence brain health and mood through neurotrophic and psychological pathways. This study compared the effects of metformin versus insulin on cognitive performance, neurotrophic factors, and mood in Egyptian patients with T2DM. This cross-sectional study in...

Talaat Abd El-Fatah Abd El-Aaty, Mai Hesham Badrah, Dalia Abd Elmoate Elnily et al. · 0 citations
Oct 2026

Brain and cognitive correlates of FKBP5: methylation patterns in schizophrenia.

Schizophrenia (SZ) is a neurodevelopmental disorder influenced by genetic and environmental factors. The stress-related gene FKBP5 shows genetic, epigenetic, and expression variability associated with SZ. Although FKBP5 methylation has been related to brain structural changes in psychiatric conditions, its role in the...

M. Latorre-Guardia, C. Almodóvar-Payá, I. París-Gómez et al. · 0 citations
Open access Sep 2026

Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer’s disease

Activation of the NLRP3 inflammasome pathway and dysfunction of brain-derived neurotrophic factor (BDNF) are both implicated in the pathogenesis of Alzheimer’s disease (AD). While in vitro and in vivo models support these mechanisms, there is little research investigating their relationship in human brain tissue, and w...

Hao Tang, H. Fachim, M. Harte et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.