Sep 2026· Journal of neural transmission· Vol 133, pp. 2787 - 2798· 0 citations· 71 references
Medicine
TL;DR
A significant BDNF-mediated pathway was identified in the association between NGAL and cognitive function and in patients with DNS, those with SCI exhibited lower plasma levels of NGAL, BDNF and EGF.
Abstract Background Neuroinflammation has been proposed as a key pathophysiological mechanism underlying treatment-resistant schizophrenia (TRS). Interleukin-6 (IL-6) has been reported as a trait-related inflammatory marker in schizophrenia; however, data focusing specifically on TRS and the impact of clozapine treatme...
Y. Suzuki, K. Endo, S. Yokokawa et al.· International Journal of Neu...· 0 citations
Neuroinflammation is a key pathophysiological mechanism underlying treatment-resistant schizophrenia (TRS). Interleukin (IL)-6 is a trait-related biomarker that exhibits consistently elevated levels in schizophrenia. However, studies focusing on TRS and examining the associations of clozapine treatment with inflammator...
Yuhei Suzuki, Kota Endo, Shuuho Yokokawa et al.· Psychiatry Research· 0 citations
Though not a feature of early or mid-adulthood, declining serum BDNF becomes pronounced in older age, providing a reference point for future studies examining BDNF's relation to cognitive aging and neurodegenerative risk.
Z.-X. Wang, X. Li, H. Dingsdale· medRxiv· 0 citations
Type 2 diabetes mellitus (T2DM) and antidiabetic therapy may influence brain health and mood through neurotrophic and psychological pathways. This study compared the effects of metformin versus insulin on cognitive performance, neurotrophic factors, and mood in Egyptian patients with T2DM. This cross-sectional study in...
Talaat Abd El-Fatah Abd El-Aaty, Mai Hesham Badrah, Dalia Abd Elmoate Elnily et al.· The Egyptian Journal of Inte...· 0 citations
Schizophrenia (SZ) is a neurodevelopmental disorder influenced by genetic and environmental factors. The stress-related gene FKBP5 shows genetic, epigenetic, and expression variability associated with SZ. Although FKBP5 methylation has been related to brain structural changes in psychiatric conditions, its role in the...
M. Latorre-Guardia, C. Almodóvar-Payá, I. París-Gómez et al.· Progress in Neuro-psychophar...· 0 citations
Activation of the NLRP3 inflammasome pathway and dysfunction of brain-derived neurotrophic factor (BDNF) are both implicated in the pathogenesis of Alzheimer’s disease (AD). While in vitro and in vivo models support these mechanisms, there is little research investigating their relationship in human brain tissue, and w...
Hao Tang, H. Fachim, M. Harte et al.· Journal of neural transmissi...· 0 citations
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