Dec 2026· Journal of Cell Biology· Vol 225 12· 0 citations
Medicine
TL;DR
It is reported that Drosophila neural stem cells cluster centromeres near the nuclear envelope, adjacent to the apical centrosome, and proposed that fly neural stem cells translate their inherent polarity into stereotypical chromatin organization, potentially influencing cell-fate decisions and stem cell behavior.
Centromeres link chromosomes to spindle microtubules to direct their segregation during mitosis. The vertebrate centromere is built on two critical DNA-binding proteins, the histone H3-variant CENP-A and histone fold protein CENP-T. CENP-T is a potent scaffold for kinetochore assembly, such that concentrating it at ect...
Océane Marescal, Kuan-Chung Su, Matteo Di Bernardo et al.· bioRxiv· 0 citations
Cohesin, a ring-shaped SMC complex, mediates sister-chromatid cohesion, DNA repair, and genome folding via loop extrusion. Pluripotent and somatic cells were thought to rely solely on mitotic cohesin (SMC1A, SMC3, RAD21, STAG1/STAG2), while meiosis-specific subunits (SMC1B, REC8, STAG3) were considered germline-restric...
Min-Cho Soo, Young Eun Kim, Eui-Hwan Choi· Molecular Therapy: Nucleic A...· 0 citations
Kinetochores are complex protein assemblies at centromeres that direct and regulate chromosome segregation1. During gamete formation by meiosis, kinetochore specialisations drive two sequential and distinct segregation events to partition half the genome to the offspring2,3. Age-dependent segregation errors in human oo...
G. Pieper, Niamh O'Loughlin, M. Aboelenain et al.· bioRxiv· 0 citations
The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalian oocytes it remains unclear whether centromere...
Y. Yun, Simon I. R. Lane, Zi-Yang Guo et al.· Communications Biology· 0 citations
It is shown that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing, and single-molecule multi-omic sequencing and imaging-based CRISPR screening demonstrate enhanced ecDNA hub formation, H3K27ac and H3K9me3 bivalency, late DNA replication, long...
Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al.· bioRxiv· 0 citations
The meiotic chromosome structure, defined by the axis-chromatin loop organization, is essential for proper homologue synapsis through the formation of the synaptonemal complex, and faithful homologous recombination. Here, we show that the conserved SMC-condensin I complex, which shapes the genome through chromatin loop...
Laurine Dal Toe, Boubou Diagouraga, A. Nore et al.· bioRxiv· 0 citations
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