TL;DR
Overall, chromatin 3D conformation integrates information from multiple molecular features, and thus it may represent a key to decoding cancer phenotypes.
The unique 3D chromatin variation pattern in cancers may become a new biomarker and provide a theoretical basis for epigenetic therapy targeting chromatin spatial organization.
A unified view is provided of how genome structure is established, how it relates to function, and how its disruption contributes to tumorigenesis, suggesting that alterations in genome structure can, in some contexts, actively reshape oncogenic programs.
A comprehensive synthesis of the mechanisms and functional roles of classical chromatin remodelers within both physiological and neoplastic contexts is provided and a hierarchical framework that distinguishes between 'first-level' and 'higher-order' chromatin remodeling is proposed.
This study finds that the proposed approach to estimate structural disruptions resulting from genetic mutations based on the information of chromatin interactions is capable of iden-tifying structurally disruptive mutations and providing insights into the structure of the genome and biological processes relevant to the...
Current CRISPR/dCas-based approaches for engineering three-dimensional genome architecture are summarized, their mechanistic basis and applications are discussed, and emerging therapeutic opportunities and major technical challenges in the field are highlighted.
The role of nuclear architecture in tumorigenesis, the contribution of lamins to chromatin organization, and the emerging epigenetic control of lamins in cancer progression and metastasis are discussed.
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