Oct 2026· Medical Oncology· Vol 43· 0 citations· 54 references
Medicine
TL;DR
Overall, this study identifies key molecular determinants of melanoma progression and provides mechanistic evidence explaining carboplatin’s therapeutic activity through modulation of dysregulated transcriptomic hubs and offers a valuable strategy for biomarker discovery and mechanistic evaluation of clinically used agents in melanoma research.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, characterized by rapid progression and high resistance to conventional therapies. Recent studies on differential gene expression have contributed to a deeper understanding of the molecular mechanisms underlying its pathogenes...
Luciana Dai Pra Penteado, J. Marcon, Scheila de Avila e Silva· Revista de Estudos Interdisc...· 0 citations
A comprehensive molecular profile of melanomaassociated genes is provided, identifying critical pathways that could serve as potential therapeutic targets and associations with specific metabolites and drug responses offer new avenues for personalized medicine approaches in melanoma treatment.
J. Brahmaiah, U. Adiga, Vijay Kumar et al.· Research journal of biotechn...· 0 citations
Hodgkin Lymphoma (HL) is a haematological malignancy characterized by the abnormal proliferation of malignant B lymphocytes within an inflammatory microenvironment. Despite advances in therapeutic strategies, a subset of patients continues to experience relapse or treatment resistance, highlighting the need for improve...
S. Ankitha, Nitya Krishnasamy, S. Selvam et al.· Egyptian Journal of Medical...· 0 citations
This study provides a hypothesis-generating framework for future biomarker-guided combination strategies, which requires validation in HER2-positive cohorts and experimental models.
Feng Wang, N. Mottaghi-Dastjerdi, Fatma Altameemi et al.· Iranian Journal of Basic Med...· 0 citations
The utility of integrating multiomics, pharmacogenomic, structural, and single-cell approaches for therapeutic target discovery and prioritization in cancer is demonstrated.
Dahlak Daniel Solomon, Yung-Kuo Lee, Sachin Kumar et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
Purpose: Obesity-associated colorectal cancer (CRC) involves complex molecular networks that limit the effectiveness of single-target therapies. This study aimed to develop an integrative computational pipeline for identifying key regulatory hubs and designing a multi-target-directed ligand (MTDL) capable of simultaneo...
Merve Uça Apaydın, Huseyin Guner, Resat Unal et al.· Cukurova Medical Journal· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
