ZUP1 contributes to the maintenance of cisplatin-resistant growth and is associated with enhanced Treg-related immunosuppressive signaling in NSCLC and may serve as a preliminary natural-product lead for further target- validation and combination studies.
Wan Xiong, Zhi-Xuan Deng, Fang-Yong Ding et al.· Scientific Reports· 0 citations
These findings identify the FOXD1/β-catenin/DARS2 axis as a potential therapeutic target for overcoming cisplatin resistance in BLCA clinically and promote cisplatin resistance in BLCA.
Xian-Yong Li, Ming-Qiang Su, Jing-Xian Luo et al.· Urologic oncology· 0 citations
identifies IDO1 as a key regulator of oxidative stress-associated, caspase-dependent apoptosis in gastric cancer and suggests that targeting IDO1 in combination with platinum-based chemotherapy represents a promising strategy to enhance the efficacy of gastric cancer treatment.
Negar Taghavi Pourianazar, Narin Abdullah, A. Ilvan· Current Issues in Molecular...· 0 citations
This study verified that POLD1 was markedly overexpressed in cisplatin-resistant BC tissues and cells and demonstrated that POLD1 knockdown remarkably impaired DDR capacity in cisplatin-resistant BC cells and restored their chemosensitivity to cisplatin in vitro.
Biao Zhang, Hong Chang, Cheng Wang et al.· Cancers· 0 citations
The findings suggest that TNF-α responsiveness, cIAP1 (BIRC2)-related signaling, and the ability of cancer cells to activate apoptotic pathways, particularly caspase-8, may serve as potential biomarkers for identifying tumors more likely to respond to Birinapant-based combination therapies.
Elham Shahnazi, Arman Rostamlou, Aras Gezer et al.· Cancer Chemotherapy and Phar...· 0 citations
In vivo studies showed that SLC7A11 suppressed tumor growth and overcame paclitaxel resistance in OC, accompanied by upregulated autophagy-related markers (LC3B, LC3B-II/I, and LAMP1), which underscore the significance of the SLC7A11/KLF2-autophagy regulatory axis in OC paclitaxel resistance.
Xiao-Ying Chen, Yao Ke, Shan-Zhou Xie et al.· Biology Direct· 0 citations
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