Sep 2026· Cancer Chemotherapy and Pharmacology· Vol 96· 0 citations· 48 references
Medicine
TL;DR
The findings suggest that TNF-α responsiveness, cIAP1 (BIRC2)-related signaling, and the ability of cancer cells to activate apoptotic pathways, particularly caspase-8, may serve as potential biomarkers for identifying tumors more likely to respond to Birinapant-based combination therapies.
It is suggested that gramine inhibits malignant progression and attenuates cisplatin resistance in OC cells, at least in part, through blockade of the PDK1/AKT pathway.
Hai-Yan Wang, Ruiming Zheng, Bujun Wang et al.· Experimental and Therapeutic...· 0 citations
Lung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the need for improved therapeutic strategies and adjunct treatment approaches. In this study, we investigated the anticancer effects of tomentosin in A549 cells and evaluated the cellular response to its combined exposure with cispl...
Hilal Nakkaş, Beyza Ecem Oz-Bedir, Emine Terzi et al.· Current Issues in Molecular...· 0 citations
Background/Aim: Sorafenib is a standard targeted therapy for renal cell carcinoma; however, resistance and limited efficacy remain clinical challenges. Magnolol, a bioactive compound derived from Magnolia officinalis, exhibits anti-cancer properties, and may enhance therapeutic responses. This study investigated whethe...
Che-Cheng Chang, Man-Yun Hung, Yueh-Shan Weng et al.· In Vivo· 0 citations
These findings identify the FOXD1/β-catenin/DARS2 axis as a potential therapeutic target for overcoming cisplatin resistance in BLCA clinically and promote cisplatin resistance in BLCA.
Xian-Yong Li, Ming-Qiang Su, Jing-Xian Luo et al.· Urologic oncology· 0 citations
It was revealed that BLA could reduce MCF-7 cell viability, adhesion, and migration while elevating intracellular ROS, autophagy, and apoptosis in an amount-dependent way and that BLA may be a natural anti-cancer agent to prevent BC metastasis.
Xinyuan Niu, Periyannan Velu, A. Vijayalakshmi· Journal of Pharmaceutical In...· 0 citations
Findings provide the first evidence that PD16 exerts pro-apoptotic effects in CRC cells through the AKT/GSK3β pathway inhibition, thereby confirming it as a valuable novel therapeutic candidate for CRC.
M. Yao, Wei Zhang, Dong Xu et al.· European Journal of Pharmaco...· 0 citations
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