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GATA6-mediated transcriptional activation and METTL3/IGF2BP2-dependent post-transcriptional stabilization upregulate CDC20 to promote the malignant progression of colorectal cancer and immune escape

Yuyu Wang Xinfei Wang Yongsheng Chang Lu Yang Daiyuan Dong Yan Yang Xiaohe Guo
Jul 2026 · Human Cell · Vol 39 · 0 citations · 41 references
Medicine

TL;DR

CDC20, upregulated transcriptionally by GATA6 and post-transcriptionally by METTL3, drove CRC progression, angiogenesis, and immune evasion and reversed the inhibitory effects of METTL3 knockdown on CRC cell malignancy and immune escape.

DOI PubMed Semantic Scholar
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