Pyrogallol inhibits T cell lymphoma growth by mediating G2/M phase cell cycle arrest, apoptosis, glycolysis and immune evasion: an implication of AKT pathway
Overall, this investigation demonstrates that pyrogallol exerts tumor growth inhibitory effect in T lymphoma cells by modulating the cell cycle, apoptosis, glucose metabolism, and immune evasion in an AKT-dependent manner.
Capsaicin, the principal bioactive compound of chilli peppers, has emerged as a promising natural molecule with anticancer potential in several malignancies, including colorectal cancer. However, the molecular mechanisms underlying its effects in colorectal cancer cells remain incompletely understood. In the present st...
Hla Sudan, Sofia Passaponti, R. Romagnoli et al.· International Journal of Mol...· 0 citations
It is demonstrated that Agrimol B significantly reduces leukemia burden in an Acute Monocytic Leukemia (AMoL) mouse model and suppresses proliferation, invasion, and migration of THP-1 cells in vitro.
Ting Ma, Qi Wang, Hao Wang et al.· Cancer Treatment and Researc...· 0 citations
Co-treatment with brusatol and venetoclax strengthens cell cycle arrest, proliferation inhibition and apoptosis induction in AML cells compared with single drug treatment, and enhances the anti-leukemic activity of venetoclax.
Xuan Chu, Zhang-Yin Ren, Jiao-Jiao Deng et al.· Cell Biochemistry and Biophy...· 0 citations
T-cell lymphoma (TCL) is a malignant tumor caused by abnormal proliferation of T cells, and its specific pathogenesis remains unclear. Currently, there is still a lack of highly effective therapeutic agents in clinic. As a semi-terpene lactone compound, Alantolactone (ATL) is mainly used to treat diseases such as asthm...
Initial evidence is provided that marbofloxacin induces metabolic and molecular rewiring in BC, highlighting its promise as a repositionable therapeutic candidate.
M. Yavuz, F. R. P. Dewi, Ilknur Keskin et al.· Pharmaceuticals· 0 citations
It is suggested that QUR concurrently elicits molecular hallmarks of ICD and activates the cGAS‑STING pathway through mtDNA release in HCC cells, which provides a preliminary mechanistic basis for exploring QUR as an immunomodulatory agent for HCC.
