Review

Genetic association of immunosenescence to immune decline

M. Alshahrani Zahraa A. Alkhafaje Uday Abdul-Reda Hussein Zahraa Adel O. Alkadir A. Aldulaimi R. Jameel Rafid Jihad Albadr M. Alwan A. Smerat

Jul 2026 · Immunogenetics · Vol 78 · 0 citations · 101 references

Medicine

TL;DR

This review discusses how inherited variation in cytokine-regulatory pathways may influence IL-6, TNF-α, interferon, and TGF-β signaling, thereby contributing to inflammatory set points that favor chronic immune activation and inflammaging.

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